ArticleScientific reports2015
Normal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- From Adipose Dysfunction to Multi-Organ Steatosis: Defining the Metabolic Steatotic Axis.Current issues in molecular biology · 2026Review
- Association Between Liver Enzymes and Metabolic Syndrome: A Population-Based Cross-Sectional Study of the Bandar Kong Cohort Study.International journal of hepatology · 2026Article
- The Comparison of Insulin Resistance Between Normal and Early Menopause Women Younger than Fifty Years Old by Machine Learning Methods.Diagnostics (Basel, Switzerland) · 2025Article
- Comparison Between the Impact of Diabetes Mellitus on Liver Diseases and Vice Versa Among Saudi and Egyptian Patients.Healthcare (Basel, Switzerland) · 2025Article
- Dynamic chronological changes of upper reference limits for liver enzymes in the nationwide population: the Korean National Health Insurance Service-National Sample Cohort 2002-2013.Archives of medical science : AMS · 2024Article
- AnchorFCI: harnessing genetic anchors for enhanced causal discovery of cardiometabolic disease pathways.Frontiers in genetics · 2024Article
- Metabolic syndrome and transaminases: systematic review and meta-analysis.Diabetology & metabolic syndrome · 2023Review
- [Intersectoral management of patients with abnormal liver enzymes and non-alcoholic fatty liver disease (NAFLD)].Zeitschrift fur Gastroenterologie · 2023Article
- Association between liver enzymes and metabolic syndrome in Canadian adults: results from the Canadian health measures survey - cycles 3 &4.Journal of diabetes and metabolic disorders · 2022Article
- Proinflammatory Polyphosphate Increases in Plasma of Obese Children with Insulin Resistance and Adults with Severe Type 2 Diabetes.Nutrients · 2022Article
- DCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases.Journal of diabetes and its complications · 2022Review
- Development and Validation of a Simple Risk Model for Predicting Metabolic Syndrome (MetS) in Midlife: A Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Machine learning and deep learning predictive models for type 2 diabetes: a systematic review.Diabetology & metabolic syndrome · 2021Review
- Associations between elevated kidney and liver biomarker ratios, metabolic syndrome and all-cause and coronary heart disease (CHD) mortality: analysis of the U.S. National Health and Nutrition Examination Survey (NHANES).BMC cardiovascular disorders · 2021Article
- Biochemistry and Immune Biomarkers Indicate Interacting Effects of Pre- and Postnatal Stressors in Pigs across Sexes.Animals : an open access journal from MDPI · 2021Article
- [Histopathological diagnosis and differential diagnosis of nonalcoholic fatty liver disease].Der Pathologe · 2020Review
- Risk of metabolic syndrome in participants within the normal range of alanine aminotransferase: A population-based nationwide study.PloS one · 2020Article
- Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction.Archives of medical science : AMS · 2020Article
- Article
- Association of Inflammatory and Liver Markers with Cardiometabolic Risk Factors in Patients with Depression.Indian journal of clinical biochemistry : IJCB · 2019Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Key features of the metabolic syndrome are insulin resistance and diabetes. The liver as central metabolic organ is not only affected by the metabolic syndrome as non-alcoholic fatty liver disease (NAFLD), but may contribute to insulin resistance and metabolic alterations. We aimed to identify potential associations between liver injury markers and diabetes in the population-based Heinz Nixdorf RECALL Study. Demographic and laboratory data were analyzed in participants (n = 4814, age 45 to 75 y). ALT and AST values were significantly higher in males than in females. Mean BMI was 27.9 kg/m(2) and type-2-diabetes (known and unkown) was present in 656 participants (13.7%). Adiponectin and vitamin D both correlated inversely with BMI. ALT, AST, and GGT correlated with BMI, CRP and HbA1c and inversely correlated with adiponectin levels. Logistic regression models using HbA1c and adiponectin or HbA1c and BMI were able to predict diabetes with high accuracy. Transaminase levels within normal ranges were closely associated with the BMI and diabetes risk. Transaminase levels and adiponectin were inversely associated. Re-assessment of current normal range limits should be considered, to provide a more exact indicator for chronic metabolic liver injury, in particular to reflect the situation in diabetic or obese individuals.
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