ArticleNature communications2015
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- IL-1β and IL-6 synergistically drive murine TFH cell differentiation and maintenance in vitro.Immunology and cell biology · 2026Article
- MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in Macrophages.International journal of molecular sciences · 2026Article
- The protective role of kakkalide in sepsis-induced intestinal barrier dysfunction via inhibition of NF-κB pathway activation.Journal of clinical biochemistry and nutrition · 2025Article
- Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential.Molecular cell · 2022Article
- Commercial ChIP-Seq Library Preparation Kits Performed Differently for Different Classes of Protein Targets.Journal of biomolecular techniques : JBT · 2022Article
- Beyond immune checkpoint blockade: emerging immunological strategies.Nature reviews. Drug discovery · 2021Review
- OmpA Protein-DeficientPathogens (Basel, Switzerland) · 2021Article
- Transcriptional Regulation of Inflammasomes.International journal of molecular sciences · 2020Review
- Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.Journal of inflammation (London, England) · 2020Article
- Interleukin-21 (IL-21) Downregulates Dendritic Cell Cytokine Responses to Helicobacter pylori and Modulates T Lymphocyte IL-17A Expression in Peyer's Patches during Infection.Infection and immunity · 2019Article
- Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages.Clinical and experimental immunology · 2017Article
- Advances of the interleukin-21 signaling pathway in immunity and angiogenesis.Biomedical reports · 2016Article
- Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- IL-21 Signaling in Immunity.F1000Research · 2016Review
- Heat stress combined with lipopolysaccharide alter the activity and superficial molecules of peripheral monocytes.International journal of immunopathology and pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. Here we show that IL-21 unexpectedly induces IL-1β production in conventional dendritic cells (cDCs) via a STAT3-dependent but NF-κB-independent pathway. IL-21 does not induce Il1b expression in CD4(+) T cells, with differential histone marks present in these cells versus cDCs. IL-21-induced IL-1β processing in cDCs does not require caspase-1 or caspase-8 but depends on IL-21-mediated death and activation of serine protease(s). Moreover, STAT3-dependent IL-1β expression in cDCs at least partially explains the IL-21-mediated pathologic response occurring during infection with pneumonia virus of mice. These results demonstrate lineage-restricted IL-21-induced IL-1β via a non-canonical pathway and provide evidence for its importance in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.