ArticleBrain pathology (Zurich, Switzerland)2016
Combined Ex Vivo 9.4T MRI and Quantitative Histopathological Study in Normal and Pathological Neocortical Resections in Focal Epilepsy.
Article in Brain pathology (Zurich, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Ex vivo ultra-high field magnetic resonance imaging of human epileptogenic specimens from primarily the temporal lobe: A systematic review.Neuroradiology · 2025Pooled it
- Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology.NeuroImage · 2021Pooled it
- Ultra-high field magnetic resonance imaging in human epilepsy: A systematic review.NeuroImage. Clinical · 2021Pooled it
- Pooled it
- Clinical use and radiological yield of magnetic resonance fingerprinting in epilepsy.Epilepsia · 2026Article
- In vivo 9.4 Tesla MRI of a patient with drug-resistant epilepsy: Technical report.Acta neurochirurgica · 2025Article
- Temporopolar blurring signifies abnormalities of white matter in mesial temporal lobe epilepsy.Annals of clinical and translational neurology · 2024Article
- Advances in magnetic resonance imaging for the assessment of paediatric focal epilepsy: a narrative review.Translational pediatrics · 2024Review
- Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2023Article
- Acquisition and Analysis of Excised Neocortex from Pediatric Patients with Focal Cortical Dysplasia Using Mesoscale Diffusion MRI.Diagnostics (Basel, Switzerland) · 2023Article
- Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status.Brain : a journal of neurology · 2023Review
- Black Line Sign in Focal Cortical Dysplasia IIB: A 7T MRI and Electroclinicopathologic Study.Neurology · 2022Article
- Fiber ball white matter modeling in focal epilepsy.Human brain mapping · 2021Article
- MRI and pathology correlations in the medulla in sudden unexpected death in epilepsy (SUDEP): a postmortem study.Neuropathology and applied neurobiology · 2021Article
- Ultra-High-Field Targeted Imaging of Focal Cortical Dysplasia: The Intracortical Black Line Sign in Type IIb.AJNR. American journal of neuroradiology · 2019Article
- Trajectories of brain remodeling in temporal lobe epilepsy.Journal of neurology · 2019Article
- White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.Annals of clinical and translational neurology · 2019Article
- HISTOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Multilayer Approach.Retina (Philadelphia, Pa.) · 2018Article
- High resolution anatomical and quantitative MRI of the entire human occipital lobe ex vivo at 9.4T.NeuroImage · 2018Article
- Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia?Brain pathology (Zurich, Switzerland) · 2018Article
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Abstract
High-resolution magnetic resonance imaging (MRI) may improve the preoperative diagnosis of focal cortical dysplasia (FCD) in epilepsy. Quantitative 9.4T MRI was carried out (T1, T2, T2* and magnetization transfer ratio) on 13 cortical resections, representing pathologically confirmed FCD (five cases) and normal cortex. Quantitative immunohistochemistry for myelination (myelin basic protein/SMI94), neuronal populations [microtubule-associated protein 2 (MAP2), neurofilament (SMI31, SMI32), synaptophysin, NeuN, calbindin], reactive glia (GFAP), microglia (CD68) and blood-brain barrier permeability (albumin) was carried out in 43 regions of interest (ROI) from normal and abnormal white matter and cortex. MRI was spatially aligned and quantitative analysis carried out on corresponding ROI. Line profile analysis (LPA) of intensity gradients through the cortex was carried out on MRI and immunostained sections. An inverse correlation was noted between myelin/SMI94 and T1, T2 (P < 0.005) and T2* (P < 0.05; Spearman's correlation) and a positive correlation between neuronal MAP2 and T1 (P < 0.005) and T2* (P < 0.05) over all ROI. Similar pathology-MRI correlations were observed for histologically unremarkable white matter ROI only. LPA showed altered gradient contours in regions of FCD, reflecting abnormal cortical lamination and myelo-architecture, including a preoperatively undetected FCD case. This study demonstrates the ability of quantitative 9.4T MRI to detect subtle differences in neuronal numbers and myelination in histologically normal appearing white matter and LPA in the evaluation of cortical dyslamination. These methods may be translatable to the in vivo detection of mild cortical malformations.
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