Evidence map›Paper›PMID 26268901›Full record

ArticleNeurology2015

Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis.

Stephanie A Grover, Berengere Aubert-Broche, Dumitru Fetco, D Louis Collins, Douglas L Arnold, Marcia Finlayson, Brenda L Banwell, Robert W Motl, E Ann Yeh

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04660227 nacompletednot on this mapstarted 2020, after this paper: background citation

Effectiveness of Exercise Training in Pediatric-Onset Multiple Sclerosis Patients

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2020 to 2022Enrolled20ConditionsPediatric Multiple SclerosisArmsExercise Trainning, Control Group
NCT07257900 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Video Game-Based Exercise Training on Physical Activity, Balance, Fatigue, and Quality of Life in Pediatric-Onset Multiple Sclerosis Patients

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2025 to 2027Enrolled30ConditionsPediatric-Onset Multiple Sclerosis (POMS), Exercise TrainingArmsStructured Functional Exercise Program, Exergaming Rehabilitation
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 75 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Built-environment correlates of physical activity in youth with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Article
  5. Review
  6. A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  7. Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  8. Therapeutic Advances in Pediatric Multiple Sclerosis.Children (Basel, Switzerland) · 2025
    Review
  9. Observational
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  11. Pediatric Multiple Sclerosis: Changing the Trajectory of Progression.Current neurology and neuroscience reports · 2023
    Review
  12. Article
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  14. Article
  15. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Stephanie A GroverFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
Berengere Aubert-BrocheFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
Dumitru FetcoFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
D Louis CollinsFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
Douglas L ArnoldFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
Marcia FinlaysonFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
Brenda L BanwellFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
Robert W MotlFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
E Ann YehFrom the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign. ann.yeh@sickkids.ca.
Montreal Neurological Institute and Hospital · CAQueen's University · CAMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between physical activity (PA) and multiple sclerosis (MS) disease activity, depression, and fatigue in a cohort of children with MS and monophasic acquired demyelinating syndrome (mono-ADS).

methodsIn this cross-sectional study of consecutive patients attending a specialized pediatric MS clinic, we administered the PedsQL Multidimensional Fatigue Scale, Center for Epidemiological Studies Depression Scale, and Godin Leisure-Time Exercise Questionnaire. Quantitative MRI analysis was performed to obtain whole brain and T2 lesion volume in a subset of participants (n = 60).

resultsA total of 110 patients (79 mono-ADS; 31 MS; 5-18 years; M:F 1:1.2) were included. Patients with MS reported less strenuous (33.21 ± 31.88 metabolic equivalents [METs] vs 15.97 ± 22.73 METs, p = 0.002) and total (44.48 ± 39.35 METs vs 67.28 ± 59.65 METs; p = 0.0291) PA than those with mono-ADS. Patients with MS who reported greater amounts of moderate PA METs had fewer sleep/rest fatigue symptoms (r = -0.4). Participation in strenuous PA was associated with smaller T2 lesion volumes (r = -0.66) and lower annualized relapse rate (r = -0.66). No associations were found between total brain volume and participation in PA.

conclusionsChildren with MS are less physically active than children with mono-ADS. Reasons for this are unclear, but may be related to ongoing disease activity, perceived limitations, or symptoms such as depression or fatigue. Children with MS reporting higher levels of strenuous PA had lower T2 lesion volumes and lower relapse rates, suggesting a potential protective effect of strenuous PA in this population. Further longitudinal studies are needed to establish the relationship of PA to MS symptoms and disease activity in this population.

Indexed as

Cost of IllnessAdolescentChildChild, PreschoolCross-Sectional StudiesDepressionExerciseFatigueFemaleHumansMaleMotor ActivityMultiple Sclerosis

Identifiers

PMID26268901
PMCPMC4653106
OpenAlexW1855869100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.