ArticleJournal of magnetic resonance imaging : JMRI2016
On the optimization of imaging protocol for the mapping of cerebrovascular reactivity.
Article in Journal of magnetic resonance imaging : JMRI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniquesJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Pooled it
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Blood-oxygenation-level-dependent (BOLD) MRI responses to COMagnetic resonance imaging · 2025Article
- The influence of cardiovascular fitness and ventilatory efficiency on fMRI assessed cerebrovascular reactivity in older adults.Frontiers in physiology · 2025Article
- Cerebrovascular reactivity mapping using breath-hold BOLD-fMRI: Comparison of signal models combined with voxelwise lag optimization.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge.NeuroImage · 2021Article
- MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Improving the Breath-Holding CVR Measurement Using the Multiband Multi-Echo EPI Sequence.Frontiers in physiology · 2021Article
- Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance.Neurology · 2020Article
- Article
- The association between BOLD-based cerebrovascular reactivity (CVR) and end-tidal CONeuroImage · 2020Article
- Review
- Vascular Abnormalities within Normal Appearing Tissue in Chronic Traumatic Brain Injury.Journal of neurotrauma · 2018Article
- Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI.NeuroImage · 2017Article
- Simultaneous multi-slice (SMS) acquisition enhances the sensitivity of hemodynamic mapping using gas challenges.NMR in biomedicine · 2016Article
- Quantitative mapping of cerebrovascular reactivity using resting-state BOLD fMRI: Validation in healthy adults.NeuroImage · 2016Article
- The relationships between age, associative memory performance, and the neural correlates of successful associative memory encoding.Neurobiology of aging · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundTo devise an improved blood-oxygen-level-dependent (BOLD) imaging protocol for cerebrovascular reactivity (CVR) measurement that can remove a known artifact of negative values.
methodsTheoretical and simulation studies were first performed to understand the biophysical mechanism of the negative CVR signals, through which improved BOLD sequence parameters were proposed. This was achieved by equating signal intensities between cerebrospinal fluid and blood, by means of shortening the echo time (TE) of the BOLD sequence. Then, 10 healthy volunteers were recruited to participate in an experimental study, in which we compared the CVR results of two versions of the optimized ("Opt1" and "Opt2") protocols with that of the standard protocol at 3 Tesla. Two sessions were performed for each subject to test the reproducibility of all three protocols.
resultsExperimental results demonstrated that the optimized protocols resulted in elimination of negative-CVR voxels. Quantitative CVR results were compared across protocols, which show that the optimized protocols yielded smaller CVR values (Opt1: 0.16 ± 0.01 %BOLD/mmHg CO2 ; Opt2: 0.15 ± 0.01 %BOLD/mmHg CO2 ) than (P < 0.001) the standard protocol (0.21 ± 0.01 %BOLD/mmHg CO2 ), but the CNR was comparable (P = 0.1) to the standard protocol. The coefficient-of-variation between repetitions was found to be 5.6 ± 1.4%, 6.3 ± 1.6%, and 6.9 ± 0.9% for the three protocols, but there were no significant differences (P = 0.65).
conclusionBased on the theoretical and experimental results obtained from this study, we suggest that the use of a TE shorter than those used in fMRI is necessary to minimize negative artifact in CVR results.
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