Evidence map›Paper›PMID 26268434›Full record

ReviewExpert review of vaccines2015

Applications of bacillus Calmette-Guerin and recombinant bacillus Calmette-Guerin in vaccine development and tumor immunotherapy.

Yuan-qiang Zheng, Youssef W Naguib, Yixuan Dong, Yan-chun Shi, Shorgan Bou, Zhengrong Cui

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Novel molecules as the emerging trends in cancer treatment: an update.Medical oncology (Northwood, London, England) · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Variances in BCG protection against COVID-19 mortality: A global assessment.Journal of clinical tuberculosis and other mycobacterial diseases · 2021
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Proposing BCG Vaccination forMicroorganisms · 2020
    Review
  17. Vaccines Against Tuberculosis: Problems and Prospects (Review).Applied biochemistry and microbiology · 2020
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yuan-qiang ZhengInner Mongolia Key Laboratory of Molecular Biology, Inner Mongolia Medical University, Hohhot 010059, China.
Youssef W Naguib
Yixuan Dong
Yan-chun Shi
Shorgan Bou
Zhengrong Cui
The University of Texas at Austin · USInner Mongolia Medical University · CNInner Mongolia University · CN

Funding

Overcoming pancreatic tumor resistance to gemcitabineR01CA135274 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI CUI, ZHENGRONG · 2008 to 2017
$2.8M
Topical DNA immunization by modifying the hair follicle cycleR01AI078304 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI CUI, ZHENGRONG · 2008 to 2011
$1.4M
An innovative approach to improve the activity of an aluminum-containing adjuvantR21AI105789 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI CUI, ZHENGRONG · 2013 to 2014
$424k
NCI NIH HHS CA135274NCI NIH HHS R01 CA135274NIAID NIH HHS AI078304NIAID NIH HHS AI105789NIAID NIH HHS R01 AI078304NIAID NIH HHS R21 AI105789
6 · The paper itself

Abstract

Bacillus Calmette-Guerin (BCG) vaccines are attenuated live strains of Mycobacterium bovis and are among the most widely used vaccines in the world. BCG is proven to be effective in preventing severe infant meningitis and miliary tuberculosis. Intravesical instillation of BCG is also a standard treatment for non-muscle invasive bladder cancer. In the past few decades, recombinant BCG (rBCG) technology had been extensively applied to develop vaccine candidates for a variety of infectious diseases, including bacterial, viral, and parasite infections, and to improve the efficacy of BCG in bladder cancer therapy. This review is intended to show the vast applications of BCG and recombinant BCG (rBCG) in the prevention of infectious diseases and cancer immunotherapy, with a special emphasis on recent approaches and trends on both pre-clinical and clinical levels.

Indexed as

Bacterial InfectionsBacterial VaccinesCancer VaccinesDrug CarriersDrug DiscoveryHumansMycobacterium bovisNeoplasmsParasitic DiseasesVaccines, AttenuatedVaccines, SyntheticViral VaccinesVirus DiseasesBacterial VaccinesCancer VaccinesDrug CarriersVaccines, AttenuatedVaccines, SyntheticViral VaccinesBacillus Calmette-Guerinbacterial vectorbladder cancerclinical applicationsinfectious diseaserecombinant BCGtumorvaccine development

Identifiers

PMID26268434
PMCPMC4920355
OpenAlexW1843355170

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.