The relationship between mean arterial pressure and decreased glomerular filtration rate in rural areas of Northeast China.

backgroundLow mean arterial pressure (MAP) can cause low renal blood flow and damage the kidneys. However, in the general population, it remains unclear whether or not decline in renal function is related to MAP. The present study examined the relationship between MAP and decreased glomerular filtration rate(GFR) in participants aged ≥ 35 years from the Liaoning province of China.

methodsA total of 11345 representative individuals aged ≥ 5 years was selected and a cross-sectional survey was conducted from January 2012 to August 2013 to describe the gender-specific prevalence and factors associated with decreased GFR in rural areas of Liaoning Province.

resultsMen with decreased eGFR (eGFR < 60 ml/min per 1.73 m(2)) were older, and had higher meanWC, systolic and diastolic BP, PP, MAP, total fasting glucose, LDL-C ,glyceride and uric acid levels and were current drinker/smoker at the baseline (all P < 0.05). Those with low education level, low income, low physical activity, low hemoglobin and HDL-C level had decreased eGFR (all P < 0.05). In women, the results were similar to those of men, but DBP and drinking status had no associations with the eGFR at the baseline (all P < 0.05). After adjustment for age, men with MAP of > 112.2 mmHg versus ≤ 93.8 mmHg had ORs for decreased eGFR of 2.367 (95 % CI: 1.248 to 4.488) .After multivariable adjustment, an MAP of > 112.2 mmHg versus ≤ 93.8 mmHg had an OR for decreased eGFR of 3.249 (95 % CI:1.394 to 7.575) in men, whereas in women, MAP was not associated with decreased eGFR.

conclusionsMAP was associated with decreased eGFR in men, while in women MAP was not associated with decreased eGFR. These findings provide some evidence that a different adaptive response to renal regulation may exist in males and females.