ArticleBMC veterinary research2015
Changes in fatty acid composition in tissue and serum of obese cats fed a high fat diet.
Article in BMC veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Establishing diagnostic criteria for feline obesity using a highly sensitive serum amyloid A assay.Frontiers in veterinary science · 2025Article
- Metabolic Responses to High-Fat Feeding and Chronic Psychological Stress Combination.Endocrinology, diabetes & metabolism · 2024Article
- Designer meat production, carcass quality, and hemato-biochemical parameters of broilers fed dietary synbiotic derived from trimmed asparagus by-products combined with probiotic supplementation.Journal of advanced veterinary and animal research · 2022Article
- The profile of urinary lipid metabolites in cats with bacterial cystitis.The Journal of veterinary medical science · 2021Article
- Effects of silybin supplementation on nutrient digestibility, hematological parameters, liver function indices, and liver-specific mi-RNA concentration in dogs.BMC veterinary research · 2021Article
- Oleic acid in Angus and Hanwoo (Korean native cattle) fat reduced the fatty acid synthase activity in rat adipose tissues.Journal of animal science and technology · 2021Article
- Metabolic Profiling of Diabetic Cats in Remission.Frontiers in veterinary science · 2020Article
- Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system.Journal of veterinary internal medicine · 2020Article
- Sample strategies for quantification of hepatic fat fraction mean MRI in healthy cats during body weight gain.PloS one · 2020Article
- Effects of overfeeding on the fatty acid profile and stearoyl-CoA desaturase-1 indices in the liver and subcutaneous adipose tissue in cats.The Journal of veterinary medical science · 2019Article
- Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction.PLoS biology · 2019Article
- Article
- Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis.Frontiers in endocrinology · 2018Article
- Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.Stem cell reports · 2017Article
- Improvement of Liver Cell Therapy in Rats by Dietary Stearic Acid.Iranian biomedical journal · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and overweight have been frequently observed in dogs and cats in recent years as in humans. The compositions of fatty acids (FAs) in the accumulated lipids in tissues of obese animals may have important roles in the process and mechanisms related to the onset of metabolic disorders. The purpose of this study was to evaluate the effects of a high fat (HF) diet, which contained a higher proportion of saturated FAs, on FA metabolism and distribution in obese cats. Cats (N = 12) were divided into control diet group (crude fat; 16.0 %) (n = 4) or a high fat (HF) diet group (crude fat; 23.9 %) (n = 8). The HF diet contained up to 60 % of calories from fat and was rich in stearic acid. Blood samples were collected at 0, 2, 4 and 6 weeks after the feeding. Adipose and liver tissues were collected at the 6(th) week after feeding. We performed analysis of histological findings and fatty acid composition in serum and tissues.
resultsBody weights of the cats significantly increased in the HF group. The increased activities of hepatic enzymes and the accumulation of lipid droplets were found in hepatocytes in the HF group at the 6(th) week after feeding. In this study, the stearic acid (C18:0)-rich HF diet contained less oleic acid (C18:1n-9) and more linoleic acid (C18:2n-6) than the control. However, the composition of oleic acid in the liver was higher, and those of stearic acid and linoleic acid were lower in the HF group at the 6(th) week after feeding. The higher oleic acid:stearic acid ratio suggests an increase in the conversion from saturated FA to mono-unsaturated FAs, which may reflect the hepatic storage of FAs as a relatively harmless form.
conclusionThe stearic acid-rich HF diet increased hepatic lipid accumulation accompanied by the increased of hepatic oleic acid, increased serum oleic acid and activation of hepatic enzymes. These findings could be an important sign of early stages of dyslipidemia and hepatic damage. Also, the higher oleic acid:stearic acid ratio might be related to the increased activity of SCD-1, which suggests that the stearic acid-rich HF diet evoked hepatic lipogenesis in the feline liver.
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