ArticleBMC evolutionary biology2015
Rapid growth accelerates telomere attrition in a transgenic fish.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- The epigenetic impacts of pubertal acceleration following early caregiver disruptions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Directional selection, not the direction of selection, affects telomere length and copy number at ribosomal RNA loci.Scientific reports · 2024Article
- The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging.Neuroscience and biobehavioral reviews · 2023Review
- Timing of reproduction modifies transgenerational effects of chronic exposure to stressors in an annual vertebrate.Proceedings. Biological sciences · 2022Article
- Individual telomere dynamics and their links to life history in a viviparous lizard.Proceedings. Biological sciences · 2021Article
- Contrasting associations between nestling telomere length and pre and postnatal helpers' presence in a cooperatively breeding bird.Oecologia · 2021Article
- Direct and pleiotropic effects of the Masou Salmon Delta-5 Desaturase transgene in F1 channel catfish (Ictalurus punctatus).Transgenic research · 2021Article
- Ageing genetic signature of hypersomatotropism.Open biology · 2021Article
- Article
- Early Puberty and Telomere Length in Preadolescent Girls and Mothers.The Journal of pediatrics · 2020Article
- Article
- Early life growth and adult telomere length in a Filipino cohort study.American journal of human biology : the official journal of the Human Biology Council · 2019Article
- Tail loss and telomeres: consequences of large-scale tissue regeneration in a terrestrial ectotherm.Biology letters · 2019Article
- Expression of the human TRIM14 and its mutant form (P207L) promotes apoptosis in transgenic loaches.Molecular biology reports · 2018Article
- Article
- Ectothermic telomeres: it's time they came in from the cold.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Telomere length and antioxidant defense associate with parasite-induced retarded growth in wild brown trout.Oecologia · 2017Article
- Is telomere length associated with mate choice in a songbird with a high rate of extra-pair paternity?PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals rarely grow as fast as their physiologies permit despite the fitness advantages of being large. One reason may be that rapid growth is costly, resulting for example in somatic damage. The chromosomal ends, the telomeres, are particularly vulnerable to such damage, and telomere attrition thus influences the rate of ageing. Here, we used a transgenic salmon model with an artificially increased growth rate to test the hypothesis that rapid growth is traded off against the ability to maintain somatic health, assessed as telomere attrition.
resultsWe found substantial telomere attrition in transgenic fish, while maternal half-sibs growing at a lower, wild-type rate seemed better able to maintain the length of their telomeres during the same time period.
conclusionsOur results are consistent with a trade-off between rapid growth and somatic (telomere) maintenance in growth-manipulated fish. Since telomere erosion reflects cellular ageing, our findings also support theories of ageing postulating that unrepaired somatic damage is associated with senescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.