Evidence map›Paper›PMID 26268225›Full record

ArticleMalaria journal2015

On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey.

Julia Mwesigwa, Joseph Okebe, Muna Affara, Gian Luca Di Tanna, Davis Nwakanma, Omar Janha, Kevin Opondo, Koen Peeters Grietens, Jane Achan, Umberto D'Alessandro

Abstract read
In one paragraph

Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. House modifications for preventing malaria.The Cochrane database of systematic reviews · 2021
    Pooled it
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  4. Efficacy, Safety and Tolerability of Pyronaridine-artesunate in Asymptomatic Malaria-infected Individuals: a Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
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  9. Safety and Immunogenicity of ChAd63 and MVA ME-TRAP in West African Children and Infants.Molecular therapy : the journal of the American Society of Gene Therapy · 2016
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia MwesigwaMedical Research Council Unit, PO Box 273, Banjul, The Gambia. jmwesigwa@mrc.gm.
Joseph OkebeMedical Research Council Unit, PO Box 273, Banjul, The Gambia. jokebe@mrc.gm.
Muna AffaraMedical Research Council Unit, PO Box 273, Banjul, The Gambia. maffara@mrc.gm.
Gian Luca Di TannaLondon School of Hygiene and Tropical Medicine, London, UK. GianLuca.DiTanna@lshtm.ac.uk.
Davis NwakanmaMedical Research Council Unit, PO Box 273, Banjul, The Gambia. DNwakanwa@mrc.gm.
Omar JanhaMedical Research Council Unit, PO Box 273, Banjul, The Gambia. ojanha@mrc.gm.
Kevin OpondoMedical Research Council Unit, PO Box 273, Banjul, The Gambia. kopondo@mrc.gm.
Koen Peeters GrietensInstitute of Tropical Medicine, Antwerp, Belgium. kpeeters@itg.be.
Jane AchanMedical Research Council Unit, PO Box 273, Banjul, The Gambia. jachan@mrc.gm.
Umberto D'AlessandroMedical Research Council Unit, PO Box 273, Banjul, The Gambia. udalessandro@mrc.gm.

Funding

Medical Research Council MC_EX_MR/J002364/1Medical Research Council MC_UP_A900_1117Medical Research Council MR/K012126/1
6 · The paper itself

Abstract

backgroundAs indicators of burden of malaria have substantially decreased in The Gambia, reaching a pre-elimination status may be attainable. Achieving this goal requires in-depth understanding of the current burden of Plasmodium falciparum infection.

methodsA nationwide cross-sectional survey was conducted in 2012 to determine the prevalence of P. falciparum infection, and to describe its heterogeneity and associated risk factors. Finger-prick blood samples were collected for microscopy, species-specific PCR and haemoglobin measurement.

resultsA total of 9,094 participants were included and median age was 11.9 years (IQR 5, 28). Overall prevalence of P. falciparum was 16.01 % with marked heterogeneity between sites (4.32-36.75 %) and within villages in each site (1.63-49.13 %). Across all sites, 51.17 % (745/1,456) of infections were asymptomatic and 35.61 % (448/1,258) were sub-microscopic. The odds of P. falciparum infection were higher in older children; 5-15 years (OR = 1.90; 95 % CI 1.60-2.26), adults (OR = 1.48; 95 % CI 1.24-1.78) and participants with moderate anaemia (OR = 1.62; 95 % CI 1.32-1.99).

conclusionsThe current malaria control interventions are not sufficient to interrupt transmission in The Gambia as malaria prevalence is still relatively high in the eastern part of the country. New interventions aiming at interrupting transmission are needed and should be urgently evaluated.

Indexed as

AdolescentAdultChildChild, PreschoolCross-Sectional StudiesFemaleGambiaHumansInfantInfant, NewbornMalaria, FalciparumMalePrevalenceRisk FactorsYoung Adult

Identifiers

PMID26268225
PMCPMC4535679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.