ArticleNeurocritical care2015
Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension.
Article in Neurocritical care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 39 citations in OpenAlex.
- Neuroimaging markers of intracranial hypertension in cerebral venous thrombosis: A systematic review and meta-analysis.Surgical neurology international · 2025Review
- Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study.Critical care (London, England) · 2021Observational
- Effects of Positive End-Expiratory Pressure on Lung Recruitment, Respiratory Mechanics, and Intracranial Pressure in Mechanically Ventilated Brain-Injured Patients.Frontiers in physiology · 2021Article
- Early Effects of Passive Leg-Raising Test, Fluid Challenge, and Norepinephrine on Cerebral Autoregulation and Oxygenation in COVID-19 Critically Ill Patients.Frontiers in neurology · 2021Article
- Multimodal non-invasive assessment of intracranial hypertension: an observational study.Critical care (London, England) · 2020Observational
- Ultrasound non-invasive intracranial pressure assessment in paediatric neurocritical care: a pilot study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Correlation of optic nerve and optic nerve sheath diameter with intracranial pressure in pigs.PloS one · 2020Article
- How I use Transcranial Doppler.Critical care (London, England) · 2019Article
- Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice.Critical care (London, England) · 2019Review
- Use of a Doppler-Based Pulsatility Index to Evaluate Cerebral Hemodynamics in Neurocritical Patients After Hemicraniectomy.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019Article
- Cerebral haemodynamics during experimental intracranial hypertension.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Non-invasive Monitoring of Intracranial Pressure Using Transcranial Doppler Ultrasonography: Is It Possible?Neurocritical care · 2016Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn many neurological diseases, intracranial pressure (ICP) is elevated and needs to be actively managed. ICP is typically measured with an invasive transducer, which carries risks. Non-invasive techniques for monitoring ICP (nICP) have been developed. The aim of this study was to compare three different methods of transcranial Doppler (TCD) assessment of nICP in an animal model of acute intracranial hypertension.
methodsIn 28 rabbits, ICP was increased to 70-80 mmHg by infusion of Hartmann's solution into the lumbar subarachnoid space. Doppler flow velocity in the basilar artery was recorded. nICP was assessed through three different methods: Gosling's pulsatility index PI (gPI), Aaslid's method (AaICP), and a method based on diastolic blood flow velocity (FVdICP).
resultsWe found a significant correlation between nICP and ICP when all infusion experiments were combined (FVdICP: r = 0.77, AaICP: r = 0.53, gPI: r = 0.54). The ability to distinguish between raised and 'normal' values of ICP was greatest for FVdICP (AUC 0.90 at ICP >40 mmHg). When infusion experiments were considered independently, FVdICP demonstrated again the strongest correlation between changes in ICP and changes in nICP (mean r = 0.85).
conclusionsTCD-based methods of nICP monitoring are better at detecting changes of ICP occurring in time, rather than absolute prediction of ICP as a number. Of the studied methods of nICP, the method based on FVd is best to discriminate between raised and 'normal' ICP and to monitor relative changes of ICP.
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