ArticlePLoS neglected tropical diseases2015
Viral Co-infection and Leprosy Outcomes: A Cohort Study.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats (Journal of virology · 2025Article
- A case of lepromatous leprosy in a background of chronic hepatitis B infection.Journal of family medicine and primary care · 2024Article
- Burden of leprosy and associated risk factors for disabilities in Tanzania from 2017 to 2020.PloS one · 2024Article
- Bacterial, fungal and parasitic co-infections in leprosy: A scoping review.PLoS neglected tropical diseases · 2023Article
- Case report: Cyclophosphamide pulse therapy for chronic recalcitrant erythema nodosum leprosum.Frontiers in medicine · 2023Article
- Chronic type 2 reaction possibly triggered by an asymptomatic Bartonella henselae infection in a leprosy patient.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- HTLV-1 and Co-infections.Frontiers in medicine · 2022Review
- Concurrent pulmonary tuberculosis and lepromatous leprosy in a newly diagnosed HIV positive patient: a case report.BMC pulmonary medicine · 2021Article
- Macrophage Polarization in Leprosy-HIV Co-infected Patients.Frontiers in immunology · 2020Article
- [Mortality from leprosy in highly endemic contexts: integrated temporal-spatial analysis in BrazilMortalidad por lepra en zonas de alta endemicidad: análisis espacio-temporal integrado en Brasil].Revista panamericana de salud publica = Pan American journal of public health · 2019Article
- Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes.BMC infectious diseases · 2018Article
- The Correlation between Anthropometric Variables and Muscular Strength in Patients Coinfected with Leprosy and HIV.Indian journal of dermatologyArticle
- Case for diagnosis. Erythematous and infiltrated plaques in the infrahyoid region.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the host immunity in determining leprosy clinical forms and complications is well recognized, implying that changes in the immune status may interfere with several aspects of the disease. Therefore, we hypothesized that the presence of viral co-infections and associated immunological changes will have a clinical impact on leprosy outcomes. The aim of our study was to determine the clinical impact of human immunodeficiency virus (HIV), human T cell lymphotrophic virus type 1 (HTLV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infection on the development of reactions, neuritis, neuropathy and relapses. METHODOLOGY/PRINCIPAL
findingsCohort study in 245 leprosy subjects from Bahia, Brazil. Patients were followed from the time of diagnosis until at least the end of multidrug therapy. Viral co-infection was detected in 36 out of the 245 patients (14.7%). Specific co-infection rates were 10.6% for HBV, 2.9% for HIV, 2.5% for HTLV-1 and 0.8% for HCV. All four groups of co-infected patients had higher rates of neuritis and nerve function impairment compared to non co-infected leprosy subjects. The relapse rate was also higher in the co-infected group (8.3%) versus patients without co-infection (1.9%); relative risk 4.37, 95% confidence interval 1.02-18.74. CONCLUSIONS/SIGNIFICANCE: Leprosy patients should be screened for HBV, HCV, HIV and HTLV-1 co-infections. Besides contributing to better health care, this measure will facilitate the early detection of severe complications through targeting of higher risk patients.
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