Evidence map›Paper›PMID 26267861›Full record

Trial reportPloS one2015

A Randomized, Double-Blind, Sham-Controlled Trial of Transcranial Direct Current Stimulation in Attention-Deficit/Hyperactivity Disorder.

Camila Cosmo, Abrahão Fontes Baptista, Arão Nogueira de Araújo, Raphael Silva do Rosário, José Garcia Vivas Miranda, Pedro Montoya, Eduardo Pondé de Sena

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 46 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01968512 nacompletednot on this map

Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder: Contribution of the Transcranial Direct Current Stimulation in Control Inhibitory.

TypeinterventionalSponsorFederal University of BahiaRan2013 to 2014Enrolled60ConditionsAttention Deficit Hyperactivity DisorderArmsTranscranial Direct Current Stimulation, Sham
NCT04780152 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment of Efficacy and Safety of Anodal Transcranial Direct Current Stimulation (TDCS) in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemics

TypeinterventionalSponsorEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezRan2021 to 2022Enrolled172ConditionsMajor Depressive DisorderArmsTranscranial Direct Current Stimulation, Placebo-simulation of transcranial direct current stimulation, Fluoxetine Tablets
NCT05350033 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Transcranial Direct Current Stimulation on Inhibitory Control in Addictions: a Triple-blinded, Sham-controlled Clinical Trial.

TypeinterventionalSponsorUniversidad de AlmeriaRan2021 to 2022Enrolled200ConditionsSubstance-Related DisordersArmstDCS - tDCS, tDCS - Sham, Sham - tDCS, Sham - Sham
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camila CosmoPostgraduate Program, Interactive Process of Organs and Systems, Federal University of Bahia, Salvador, Bahia, Brazil; Spaulding Neuromodulation Center, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, United States of America; Bahia State Health Department (SESAB), Salvador, Bahia, Brazil; Functional Electrostimulation Laboratory, Biomorphology Department, Federal University of Bahia, Salvador, Bahia, Brazil.
Abrahão Fontes BaptistaFunctional Electrostimulation Laboratory, Biomorphology Department, Federal University of Bahia, Salvador, Bahia, Brazil; Postgraduate Program on Medicine and Human Health, School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil.
Arão Nogueira de AraújoPostgraduate Program, Interactive Process of Organs and Systems, Federal University of Bahia, Salvador, Bahia, Brazil.
Raphael Silva do RosárioInstitute of Physics, Federal University of Bahia, Salvador, Bahia, Brazil.
José Garcia Vivas MirandaInstitute of Physics, Federal University of Bahia, Salvador, Bahia, Brazil.
Pedro MontoyaResearch Institute on Health Sciences (IUNICS-IdisPa), University of the Balearic Islands, Palma, Spain.
Eduardo Pondé de SenaPostgraduate Program, Interactive Process of Organs and Systems, Federal University of Bahia, Salvador, Bahia, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent standardized treatments for cognitive impairment in attention-deficit/hyperactivity disorder remain limited and their efficacy restricted. Transcranial direct current stimulation (tDCS) is a promising tool for enhancing cognitive performance in several neuropsychiatric disorders. Nevertheless, the effects of tDCS in reducing cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD) have not yet been investigated.

methodsA parallel, randomized, double-blind, sham-controlled trial was conducted to examine the efficacy of tDCS on the modulation of inhibitory control in adults with ADHD. Thirty patients were randomly allocated to each group and performed a go/no-go task before and after a single session of either anodal stimulation (1 mA) over the left dorsolateral prefrontal cortex or sham stimulation.

resultsA nonparametric two-sample Wilcoxon rank-sum (Mann-Whitney) test revealed no significant differences between the two groups of individuals with ADHD (tDCS vs. sham) in regard to behavioral performance in the go/no go tasks. Furthermore, the effect sizes of group differences after treatment for the primary outcome measures-correct responses, impulsivity and omission errors--were small. No adverse events resulting from stimulation were reported.

conclusionAccording to these findings, there is no evidence in support of the use of anodal stimulation over the left dorsolateral prefrontal cortex as an approach for improving inhibitory control in ADHD patients. To the best of our knowledge, this is the first clinical study to assess the cognitive effects of tDCS in individuals with ADHD. Further research is needed to assess the clinical efficacy of tDCS in this population.

trial registrationClinicalTrials.gov NCT01968512.

Indexed as

Transcranial Direct Current StimulationAdultAttention Deficit Disorder with HyperactivityDouble-Blind MethodFemaleHumansMaleMiddle AgedPrefrontal Cortex

Identifiers

PMID26267861
PMCPMC4534404

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.