Evidence map›Paper›PMID 26267855›Full record

ArticleChembiochem : a European journal of chemical biology2015

The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.

Xavier Álvarez-Micó, Danilo D Rocha, Larissa A Guimarães, Andrew Ambrose, Eli Chapman, Leticia V Costa-Lotufo, James J La Clair, William Fenical

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Lessons in Organic Fluorescent Probe Discovery.Chembiochem : a European journal of chemical biology · 2021
    Review
  3. Article
  4. Review
  5. Irreversible Protein Labeling by Paal-Knorr Conjugation.Chembiochem : a European journal of chemical biology · 2017
    Article
  6. Ritterostatin GChembiochem : a European journal of chemical biology · 2017
    Article
  7. Article
  8. Color-Coded Super-Resolution Small-Molecule Imaging.Chembiochem : a European journal of chemical biology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xavier Álvarez-MicóCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, 92093-0204, USA.
Danilo D RochaDepartamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, 60.430-270, Brazil.
Larissa A GuimarãesDepartamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, 60.430-270, Brazil.
Andrew AmbroseDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, P.O. Box 210207, Tucson, AZ, 85721, USA.
Eli ChapmanDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, P.O. Box 210207, Tucson, AZ, 85721, USA.
Leticia V Costa-LotufoDepartamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, 60.430-270, Brazil.
James J La ClairDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA. jlaclair@ucsd.edu.
William FenicalCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, 92093-0204, USA. wfenical@ucsd.edu.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008804 · NIGMS · UNIVERSITY OF ARIZONA · PI MONTFORT, WILLIAM R. · 2003 to 2023
$3.9M
Antitumor-Antibiotics from Marine MicroorganismsR37CA044848 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENICAL, WILLIAM · 2004 to 2013
$3.9M
NCI NIH HHS P30 CA023100NCI NIH HHS R37 CA044848NCI NIH HHS R37-CA044848NIGMS NIH HHS T32 GM008804NINDS NIH HHS P30 NS047101
6 · The paper itself

Abstract

The cytotoxic activity of (-)-chlorizidine A, a marine alkaloid containing a unique fusion between a pyrroloisoindolone and dehydropyrrolizine, was explored by using a combination of cellular and molecular methods. Our studies began by applying preliminary SAR evidence gathered from semisynthetic bioactivity evaluations to prepare an active immunoaffinity fluorescent (IAF) probe. This probe was then used to identify two cytosolic proteins, GAPDH and hENO1, as the targets of (-)-chlorizidine A.

Indexed as

Amino Acid SequenceBiological ProductsBiomarkers, TumorDNA-Binding ProteinsDrug DiscoveryGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)GlycolysisHCT116 CellsHumansIndole AlkaloidsMolecular Sequence DataMolecular Targeted TherapyPhosphopyruvate HydrataseProteinsStreptomycesTumor Suppressor ProteinsBiological ProductsBiomarkers, TumorchlorizidineDNA-Binding ProteinsENO1 protein, humanGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)Indole AlkaloidsPhosphopyruvate HydrataseProteinsTumor Suppressor Proteinsdrug discoveryenolaseglycolysismode of actionnatural products

Identifiers

PMID26267855
PMCPMC4835225

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.