Evidence map›Paper›PMID 26267330›Full record

ArticleJournal of autism and developmental disorders2016

Re-conceptualizing ASD Within a Dimensional Framework: Positive, Negative, and Cognitive Feature Clusters.

Jennifer H Foss-Feig, James C McPartland, Alan Anticevic, Julie Wolf

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Basic Management Strategies by Life Cycle for Treatment of the Persons With Autism Spectrum Disorder.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2024
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  12. Early-onset catatonia associated withFrontiers in psychiatry · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jennifer H Foss-FeigYale University Child Study Center, 230 South Frontage Rd, New Haven, CT, 06520, USA. jennifer.foss-feig@yale.edu.
James C McPartlandYale University Child Study Center, 230 South Frontage Rd, New Haven, CT, 06520, USA. james.mcpartland@yale.edu.
Alan AnticevicDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Julie WolfYale University Child Study Center, 230 South Frontage Rd, New Haven, CT, 06520, USA.
Yale University · US

Funding

The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI DAWSON, GERALDINE · 2015 to 2024
$68.8M
Characterizing Schizophrenia Progression via Multi-modal Neuroimaging and ComputationR01MH108590 · NIMH · YALE UNIVERSITY · PI ANTICEVIC, ALAN · 2016 to 2020
$2.0M
Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling aDP5OD012109 · OD · YALE UNIVERSITY · PI ANTICEVIC, ALAN · 2012 to 2016
$1.8M
Neural markers of shared gaze during simulated social interactions in ASDR01MH100173 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2013 to 2015
$1.3M
Multimodel Assessment of Social Process Systems across Neurodevelopmental DisordersR01MH107426 · NIMH · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES, SRIHARI, VINOD H. · 2015 to 2017
$651k
NCCDPHP CDC HHS DP50D012109-02NIH HHS DP5 OD012109NIMH NIH HHS R01 MH100173NIMH NIH HHS R01MH100173NIMH NIH HHS R01 MH100173-02S1NIMH NIH HHS R01 MH107426NIMH NIH HHS R01 MH107426-01NIMH NIH HHS R01 MH108590NIMH NIH HHS U19 MH108206
6 · The paper itself

Abstract

Introduction of the National Institute of Mental Health's Research Domain Criteria and revision of diagnostic classification for Autism Spectrum Disorder in the latest diagnostic manual call for a new way of conceptualizing heterogeneous ASD features. We propose a novel conceptualization of ASD, borrowing from the schizophrenia literature in clustering ASD features along positive, negative, and cognitive dimensions. We argue that this dimensional conceptualization can offer improved ability to classify, diagnose, and treat, to apply and predict response to treatment, and to explore underlying neural and genetic alterations that may contribute to particular feature clusters. We suggest the proposed conceptualization can advance the field in a manner that may prove clinically and biologically useful for understanding and addressing heterogeneity within ASD.

Indexed as

Autism Spectrum DisorderCognitionConcept FormationHumansSymptom AssessmentUnited StatesAutism spectrum disorderClassificationDiagnosisHeterogeneityRDoCSymptoms

Identifiers

PMID26267330
PMCPMC5328688
OpenAlexW1193670752

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.