Evidence map›Paper›PMID 26267226›Full record

ReviewCurrent urology reports2015

What is the Need for Prostatic Biomarkers in Prostate Cancer Management?

Martin Spahn, Silvan Boxler, Steven Joniau, Marco Moschini, Bertrand Tombal, R Jeffrey Karnes

Abstract readReview
In one paragraph

Review in Current urology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin SpahnDepartment of Urology, Inselspital, Bern University Hospital, University of Bern, Anna Seiler Haus, CH-3010, Bern, Switzerland, martin.spahn@insel.ch.
Silvan Boxler
Steven Joniau
Marco Moschini
Bertrand Tombal
R Jeffrey Karnes

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Discriminating patients with a low risk of progression from those with lethal prostate cancer is one of the main challenges in prostate cancer management. Indeed, such discrimination is essential if we aim to avoid overtreatment in men with indolent disease and to improve survival in those men with lethal disease. We are reporting on the current literature on such prognostic tools that are now available, their clinical role and their limitations in individualizing care. There is an urgent need to incorporate such genomic tools into new platform-based clinical trial structures to further develop and validate prognostic and predictive biomarkers and provide prostate cancer patients with an effective and cost-efficient access to new drugs in the setting of personalized treatment.

Indexed as

Biomarkers, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansMalePrognosisProstatic NeoplasmsTumor MicroenvironmentBiomarkers, Tumor

Identifiers

PMID26267226
PMCPMC4534510

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.