ArticlePharmacogenomics2015
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
Article in Pharmacogenomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Machine learning models incorporating genotype and ancestry improve severe asthma risk prediction.Scientific reports · 2025Article
- Statistical and Machine Learning Analysis in Brain-Imaging Genetics: A Review of Methods.Behavior genetics · 2024Review
- Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an example.Drug and alcohol dependence · 2021Article
- Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank.Human molecular genetics · 2021Article
- Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- Association of Stress, Glucocorticoid Receptor, and FK506 Binding Protein Gene Polymorphisms With Internalizing Disorders Among HIV-Infected Children and Adolescents From Kampala and Masaka Districts-Uganda.Frontiers in pediatrics · 2021Article
- Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.Biological psychiatry · 2019Article
- ADGRL3 (LPHN3) variants predict substance use disorder.Translational psychiatry · 2019Article
- Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.Alcoholism, clinical and experimental research · 2018Article
- ADH1B: From alcoholism, natural selection, and cancer to the human phenome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Molecular psychiatry · 2018Article
- Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- The genetic epidemiology of substance use disorder: A review.Drug and alcohol dependence · 2017Review
- Non-coding variants contribute to the clinical heterogeneity of TTR amyloidosis.European journal of human genetics : EJHG · 2017Article
- Article
- Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis.BMC genomics · 2017Article
- Genome-wide association study of body mass index in subjects with alcohol dependence.Addiction biology · 2017Article
- Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.Molecular psychiatry · 2017Article
- Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimsTo understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. MATERIALS &
methodsWe investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes.
resultsWe observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes.
conclusionPopulation differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.