Evidence map›Paper›PMID 26267155›Full record

ArticlePediatric research2015

Comparison of biomarkers for systemic juvenile idiopathic arthritis.

Susan Shenoi, Jing-Ni Ou, Chester Ni, Claudia Macaubas, Vivian H Gersuk, Carol A Wallace, Elizabeth D Mellins, Anne M Stevens

Open access · bronzeAbstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Susan ShenoiCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.
Jing-Ni OuCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington.
Chester NiGenomics Core, Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington.
Claudia MacaubasDivision of Human Gene Therapy, Program in Immunology, Stanford University, Stanford, California.
Vivian H GersukGenomics Core, Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington.
Carol A WallaceCenter for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, Washington.
Elizabeth D MellinsDivision of Human Gene Therapy, Program in Immunology, Stanford University, Stanford, California.
Anne M StevensDivision of Rheumatology, Department of Pediatrics, University of Washington, Seattle, Washington.
Seattle Children's Hospital · USBenaroya Research InstituteStanford University · USUniversity of Washington · US

Funding

INSTITUTE FOR TRANSLATIONAL HEALTH SCIENCE (UL1): BPCAUL1RR025014 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$51.5M
Inflammasome function and SJIAR21AR062765 · NIAMS · STANFORD UNIVERSITY · PI MELLINS, ELIZABETH D · 2012 to 2013
$382k
Development of a Photoacoustic Quantitative Ultrasound (PAQUS) device for clinical useR43AR070071 · NIAMS · IF, LLC · PI MORRIS, RICHARD FRANKLIN · 2017 to 2017
$225k
NCRR NIH HHS UL1 RR025014NIAMS NIH HHS 1R21AR062765NIAMS NIH HHS AR7007108
6 · The paper itself

Abstract

backgroundDifferentiation of systemic juvenile idiopathic arthritis (SJIA) fever from other childhood fevers is often delayed due to the lack of reliable, specific biomarkers. We hypothesized that PD-L1 expression is dysregulated in SJIA monocytes and compared it to other candidate SJIA biomarkers.

methodsThis pilot study enrolled children with fever without source and compared PD-L1 expression on myeloid cells to C-reactive protein, erythrocyte sedimentation rate, leukocyte counts, S100A12, S100A8, S100A9, calprotectin, and procalcitonin. Logistic regression models were fit to test SJIA diagnosis with each marker used as an independent predictor. Receiver operating characteristic curves and area under curve were calculated. Gene expression profiling on a subset of samples was performed.

resultsTwenty subjects (10 active SJIA, 10 febrile non-SJIA) were enrolled. S100 proteins were significantly elevated in SJIA with >80% sensitivity and >90% specificity. PD-L1 expression was significantly lower in SJIA. Other markers were not specific for SJIA. On exploratory gene analysis, 106 genes were significant for SJIA association, and several of these are associated with immune response pathways.

conclusionIn this small cohort, S100 proteins were specific diagnostic biomarkers for SJIA in children with fever. Decreased PD-L1 surface expression on circulating myeloid cells in SJIA suggests possible mechanism for loss of peripheral immune regulation.

Indexed as

Area Under CurveArthritis, JuvenileB7-H1 AntigenBiomarkersBlood Chemical AnalysisChildChild, PreschoolDiagnosis, DifferentialFemaleGene Expression ProfilingHumansInfantMalePilot ProjectsPredictive Value of TestsPrognosisB7-H1 AntigenBiomarkersCD274 protein, humanS100 Proteins

Identifiers

PMID26267155
OpenAlexW2339347071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.