ArticleEuropean journal of nutrition2016
Rice bran prevents high-fat diet-induced inflammation and macrophage content in adipose tissue.
Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran.Foods (Basel, Switzerland) · 2023Review
- Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review.Molecules (Basel, Switzerland) · 2022Review
- Enhancement Methods of Antioxidant Capacity in Rice Bran: A Review.Foods (Basel, Switzerland) · 2022Review
- Red Rice Bran Extract Attenuates Adipogenesis and Inflammation on White Adipose Tissues in High-Fat Diet-Induced Obese Mice.Foods (Basel, Switzerland) · 2022Article
- Rice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese rats.European journal of nutrition · 2022Article
- Fermented rice bran supplementation ameliorates obesity via gut microbiota and metabolism modification in female mice.Journal of clinical biochemistry and nutrition · 2022Article
- Biological Functions and Activities of Rice Bran as a Functional Ingredient: A Review.Nutrition and metabolic insights · 2021Review
- The Absence of Adiponectin Alters Niacin's Effects on Adipose Tissue Inflammation in Mice.Nutrients · 2020Article
- Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice.Nutrients · 2020Article
- Enzyme Treatment Alters the Anti-Inflammatory Activity of the Water Extract of Wheat Germ In Vitro and In Vivo.Nutrients · 2019Article
- The anti-cancer activity and potential clinical application of rice bran extracts and fermentation products.RSC advances · 2019Review
- Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran.Integrative food, nutrition and metabolism · 2019Article
- CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity.Molecular metabolism · 2019Article
- Compositional analyses of white, brown and germinated forms of popular Malaysian rice to offer insight into the growing diet-related diseases.Journal of food and drug analysis · 2018Article
- Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway.Journal of neuroinflammation · 2016Article
- Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.Archives of biochemistry and biophysics · 2016Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe inflammatory process associated with obesity mainly arises from white adipose tissue (WAT) alterations. In the last few years, nutritional-based strategies have been positioned as promising alternatives to pharmacological approaches against these pathologies. Our aim was to determine the potential of a rice bran enzymatic extract (RBEE)-supplemented diet in the prevention of metabolic, biochemical and functional adipose tissue and macrophage changes associated with a diet-induced obesity (DIO) in mice.
methodsC57BL/6J mice were fed high-fat diet (HF), 1 and 5 % RBEE-supplemented high-fat diet (HF1 % and HF5 %, respectively) and standard diet as control. Serum cardiometabolic parameters, adipocytes size and mRNA expression of pro-inflammatory biomarkers and macrophage polarization-related genes from WAT and liver were evaluated.
resultsRBEE administration significantly decreased insulin resistance in obese mice. Serum triglycerides, total cholesterol, glucose, insulin, adiponectin and nitrites from treated mice were partially restored, mainly by 1 % RBEE-enriched diet. The incremented adipocytes size observed in HF group was reduced by RBEE treatment, being 1 % more effective than 5 % RBEE. Pro-inflammatory biomarkers in WAT such as IL-6 and IL-1β were significantly decreased in RBEE-treated mice. Adiponectin, PPARγ, TNF-α, Emr1 or M1/M2 levels were significantly restored in WAT from HF1 % compared to HF mice.
conclusionsRBEE-supplemented diet attenuated insulin resistance, dyslipidemia and morphological and functional alterations of adipose tissue in DIO mice. These benefits were accompanied by a modulating effect in adipocytes secretion and some biomarkers associated with macrophage polarization. Therefore, RBEE may be considered an alternative nutritional complement over metabolic syndrome and its complications.
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