ArticleIntensive care medicine experimental2014
'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill.
Article in Intensive care medicine experimental, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03624595 (Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Impact of sex on outcomes in septic shock patients treated with hydrocortisone.Scientific reports · 2025Observational
- Cortisol stress response after musculoskeletal surgery: a narrative review.EFORT open reviews · 2025Review
- New policies on skin-to-skin contact warrant an oxytocin-based perspective on perinatal health care.Frontiers in psychology · 2024Article
- Circadian disruption dysregulates lung gene expression associated with inflammatory lung injury.Frontiers in immunology · 2024Article
- Bidirectional Interaction of Sepsis and Sleep Disorders: The Underlying Mechanisms and Clinical Implications.Nature and science of sleep · 2024Review
- Circadian rhythm disturbance and delirium in ICU patients: a prospective cohort study.BMC anesthesiology · 2023Article
- Changes in Body Temperature Patterns Are Predictive of Mortality in Septic Shock: An Observational Study.Biology · 2023Article
- Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions.Molecular biology reports · 2023Review
- Circadian patterns of heart rate, respiratory rate and skin temperature in hospitalized COVID-19 patients.PloS one · 2022Article
- Circadian rhythms in septic shock patients.Annals of intensive care · 2021Article
- A Tangled Threesome: Circadian Rhythm, Body Temperature Variations, and the Immune System.Biology · 2021Review
- Long-Term Bed Rest Delays the Circadian Phase of Core Body Temperature.Frontiers in physiology · 2021Article
- For Whom the Clock Ticks: Clinical Chronobiology for Infectious Diseases.Frontiers in immunology · 2020Review
- Determining rhythmicity and determinism of temperature curves in septic and non-septic critically ill patients through chronobiological and recurrence quantification analysis: a pilot study.Intensive care medicine experimental · 2019Article
- Pineal gland dysfunction in Alzheimer's disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis.Molecular neurodegeneration · 2019Review
- Sleep and Circadian Rhythm in Critical Illness.Critical care (London, England) · 2019Review
- Dynamics of Vagal Activity Due to Surgery and Subsequent Rehabilitation.Frontiers in neuroscience · 2019Article
- Chronic Pain and Chronic Opioid Use After Intensive Care Discharge - Is It Time to Change Practice?Frontiers in pharmacology · 2019Review
- Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study.Annals of intensive care · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex interrelations exist between the master central clock, located in the suprachiasmatic nuclei of the hypothalamus, and several peripheral clocks, such as those found in different immune cells of the body. Moreover, external factors that are called 'timekeepers', such as light/dark and sleep/wake cycles, interact with internal clocks by synchronizing their different oscillation phases. Chronobiology is the science that studies biologic rhythms exhibiting recurrent cyclic behavior. Circadian rhythms have a duration of approximately 24 h and can be assessed through chronobiologic analysis of time series of melatonin, cortisol, and temperature. Critically ill patients experience severe circadian deregulation due to not only the lack of effective timekeepers in the intensive care unit (ICU) environment but also systemic inflammation. The latter has been found in both animal and human studies to disrupt circadian rhythmicity of all measured biomarkers. The aims of this article are to describe circadian physiology during acute stress and to discuss the effects of ICU milieu upon circadian rhythms, in order to emphasize the value of considering circadian-immune disturbance as a potential tool for personalized treatment. Thus, besides neoplastic processes, critical illness could be linked to what has been referred as 'chronomics': timing and rhythm. In addition, different therapeutic perspectives will be presented in association with environmental approaches that could restore circadian connection and hasten physical recovery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.