Trial reportIntensive care medicine2015
Predictive value for weakness and 1-year mortality of screening electrophysiology tests in the ICU.
Trial report in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00512122 (Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ICU-acquired weakness.Intensive care medicine · 2020Pooled it
- Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Impact of withholding early parenteral nutrition on 2-year mortality and functional outcome in critically ill adults.Intensive care medicine · 2024Trial
- Diagnostic Performance of the Strength-Duration Test for Bedside Screening of Critical Illness Polyneuropathy and/or Myopathy: A Prospective, Cross-Sectional Study.Muscle & nerve · 2026Article
- Review
- Early Measurement of Quadriceps Response to Neuromuscular Electrical Stimulation to Identify Future ICU-Acquired Weakness.Critical care medicine · 2026Observational
- Intensive Care Unit Acquired Weakness as a Modifiable Organ Dysfunction? A Narrative Review of Evolving Diagnostic and Therapeutic Concepts.Nutrients · 2026Review
- Rapid Diagnostic Model for Critical Illness Polyneuropathy Based on Electrophysiological Data.CNS neuroscience & therapeutics · 2025Article
- Development and validation of a machine learning model for early prediction of intensive care unit acquired weakness.Intensive care medicine experimental · 2025Article
- Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients.Critical care (London, England) · 2024Article
- Accelerometer-derived movement features as predictive biomarkers for muscle atrophy in neurocritical care: a prospective cohort study.Critical care (London, England) · 2024Observational
- Unmasking the hidden aftermath: postintensive care unit sequelae, discharge preparedness, and long-term follow-up.Critical care science · 2024Review
- Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.Critical care (London, England) · 2023Review
- Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case-control study.BMC medical imaging · 2023Article
- Early detection of ICU-acquired weakness in septic shock patients ventilated longer than 72 h.BMC pulmonary medicine · 2022Article
- Investigating the rate of skeletal muscle atrophy in men and women in the intensive care unit: a prospective observational study.Scientific reports · 2022Observational
- Machine-assisted nutritional and metabolic support.Intensive care medicine · 2022Article
- Occurrence and Effects on Weaning From Mechanical Ventilation of Intensive Care Unit Acquired and Diaphragm Weakness: A Pilot Study.Frontiers in medicine · 2022Article
- Simplified Diagnosis of Critical Illness Polyneuropathy in Patients with Prolonged Mechanical Ventilation: A Prospective Observational Cohort Study.Journal of clinical medicine · 2020Article
- Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMuscle weakness in long-stay ICU patients contributes to 1-year mortality. Whether electrophysiological screening is an alternative diagnostic tool in unconscious/uncooperative patients remains unknown. We aimed to determine the diagnostic properties of abnormal compound muscle action potential (CMAP), sensory nerve action potential (SNAP), and spontaneous electrical activity (SEA) for Medical Research Council (MRC)-defined weakness and their predictive value for 1-year mortality.
methodsData were prospectively collected during the EPaNIC trial (ClinicalTrials.gov: NCT00512122). First, sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of abnormal CMAP, SNAP, and SEA for weakness were determined. Subsequently, association between 1-year mortality and abnormal findings on electrophysiological screening was assessed by univariate and multivariate analyses correcting for weakness and other risk factors and the prediction model involved only a development phase.
resultsA total of 730 patients were electrophysiologically screened of whom 432 were tested for weakness. On day 8, normal CMAP excluded weakness with a high NPV (80.5 %). By day 15, abnormal SNAP and the presence of SEA had a high PPV (91.7 and 80.0 %, respectively). Only a reduced CMAP on day 8 was associated with higher 1-year mortality [35.6 vs 15.2 % (p < 0.001)]. This association remained significant after correction for weakness and other risk factors [OR 2.463 (95 % CI 1.113-5.452), p = 0.026]. Also among conscious/cooperative patients without weakness, reduced CMAP was independently associated with a higher likelihood of death occurring during 1 year [HR 2.818 (95 % CI 1.074-7.391), p = 0.035].
conclusionsThe diagnostic properties of electrophysiological screening vary over time. Abnormal CMAP documented early during critical illness carries information about longer-term outcome, which should be further investigated mechanistically.
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