ArticleTechniques in coloproctology2015
Implantation of autologous muscle-derived stem cells in treatment of fecal incontinence: results of an experimental pilot study.
Article in Techniques in coloproctology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Stem Cells in Clinical Trials for Pelvic Floor Disorders: a Systematic Literature Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Skeletal muscle-derived cell implantation for the treatment of sphincter-related faecal incontinence.Stem cell research & therapy · 2018Trial
- Autologous Myoblasts for the Treatment of Fecal Incontinence: Results of a Phase 2 Randomized Placebo-controlled Study (MIAS).Annals of surgery · 2018Trial
- Progress on cell therapy for skeletal muscle disorders.Advanced drug delivery reviews · 2026Review
- The Japan Society of Coloproctology Practice Guidelines for Fecal Incontinence 2024 (Revised Second Edition).Journal of the anus, rectum and colon · 2026Review
- Controversies in fecal incontinence.World journal of gastroenterology · 2025Article
- 3D spheroids versus 2D-cultured human adipose stem cells to generate smooth muscle cells in an internal anal sphincter-targeting cryoinjured mouse model.Stem cell research & therapy · 2024Article
- Differentiation of Adipose-Derived Stem Cells into Smooth Muscle Cells in an Internal Anal Sphincter-Targeting Anal Incontinence Rat Model.Journal of clinical medicine · 2023Article
- Stromal cell derived factor 1 plasmid to regenerate the anal sphincters.Journal of tissue engineering and regenerative medicine · 2022Article
- Optimization of human myoblasts culture under different media conditions for application in theAmerican journal of stem cells · 2022Article
- Review
- Generation of myogenic progenitor cell-derived smooth muscle cells for sphincter regeneration.Stem cell research & therapy · 2020Article
- Stem cell therapy for faecal incontinence: Current state and future perspectives.World journal of stem cells · 2018Review
- Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model.Stem cells translational medicine · 2018Article
- Rat model of anal sphincter injury and two approaches for stem cell administration.World journal of stem cells · 2018Article
- Perspective: autologous skeletal muscle cells for the treatment of fecal incontinence.Techniques in coloproctology · 2015Article
- Novel approach to treat fecal incontinence with muscle stem cell-based therapy.Techniques in coloproctology · 2015Article
- Cell shape characteristics of human skeletal muscle cells as a predictor of myogenic competency: A new paradigm towards precision cell therapy.Journal of tissue engineeringArticle
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to present results of the implantation of autologous myoblasts into the external anal sphincter (EAS) in ten patients with fecal incontinence.
methodsAfter anatomical and functional assessment of the patients' EAS, a vastus lateralis muscle open biopsy was performed. Stem cells were extracted from the biopsy specimens and cultured in vitro. Cell suspensions were then administered to the EAS. Patients were scheduled for follow-up visits in 6-week intervals. Total follow-up was 12 months.
resultsAll biopsy and cell implantation procedures were performed without complications. Nine of the patients completed a full 12-month follow-up. There was subjective improvement in six patients (66.7 %). In manometric examinations 18 weeks after implantation, squeeze anal pressures and high-pressure zone length increased in all patients, with particularly significant sphincter function recovery in five patients (55.6 %). Electromyographic (EMG) examination showed an increase in signal amplitude in all patients, detecting elevated numbers of propagating action potentials. Twelve months after implantation two patients experienced deterioration of continence, which was also reflected in the deterioration of manometric and EMG parameters. The remaining four patients (44.4 %) still described their continence as better than before implantation and retained satisfactory functional examination parameters.
conclusionsImplantation of autologous myoblasts gives good short-term results not only in a subjective assessment, but also in objective functional tests. It seems that this promising technology can improve the quality of life of patients with fecal incontinence, but further study is required to achieve better and more persistent results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.