Evidence map›Paper›PMID 26266659›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Elemental diet plus glutamine for the prevention of mucositis in esophageal cancer patients receiving chemotherapy: a feasibility study.

Yoshihiro Tanaka, Takao Takahashi, Kazuya Yamaguchi, Shinji Osada, Toshio Shimokawa, Kazuhiro Yoshida

Erratum issuedOpen access · hybridAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Effectiveness of glutamine in the management of oral mucositis in cancer patients: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  12. Serum diamine oxidase activity derived from response to chemotherapy affects adverse events and serum amino acid levels.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  16. What makes a good new therapeutic L-asparaginase?World journal of microbiology & biotechnology · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yoshihiro TanakaDepartment of Surgical Oncology, Gifu Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan. yoshihirotana11@hotmail.com.
Takao TakahashiDepartment of Surgical Oncology, Gifu Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan.
Kazuya YamaguchiDepartment of Surgical Oncology, Gifu Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan.
Shinji OsadaDepartment of Surgical Oncology, Gifu Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan.
Toshio ShimokawaGraduate School of Medicine and Engineering, University of Yamanashi, 4-4-37 Takeda, Kofu City, 400-8510, Japan.
Kazuhiro YoshidaDepartment of Surgical Oncology, Gifu Graduate School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan.
Gifu University · JPTakeda (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe investigated the effect of glutamine (Gln) and an elemental diet (ED) on chemotherapy-induced oral mucositis in esophageal cancer patients.

methodsThirty patients were randomized to the control group (no treatment: n = 10), Gln group (oral intake of 8910 mg Gln/day: n = 10), or Gln plus ED group (total oral intake of 8862 mg Gln/day, including the Gln in ED: n = 10). Oral administration of Gln and ED began 1 week before chemotherapy and continued during treatment. Oral mucositis was evaluated during 2 cycles of chemotherapy using Common Terminology Criteria for Adverse Events v3.0.

resultsThe incidence of grade ≥2 oral mucositis was 60 % in the control group, 70 % in the Gln group, and 10 % in the Gln plus ED group. Gln plus ED showed a significant preventive effect on the development and severity of oral mucositis. By multivariate analysis, Gln plus ED and cancer stage were independent factors affecting chemotherapy-induced oral mucositis. The percentage of change in body weight and diamine oxidase activity from before chemotherapy was higher in the Gln plus ED group than in the control group.

conclusionsOral administration of Gln plus ED may prevent chemotherapy-induced oral mucositis in esophageal cancer patients.

Indexed as

Food, FormulatedAdministration, OralAgedAged, 80 and overAmine Oxidase (Copper-Containing)Body WeightEsophageal NeoplasmsFeasibility StudiesFemaleGlutamineHumansInduction ChemotherapyMaleMiddle AgedMucositisStomatitisAmine Oxidase (Copper-Containing)GlutamineChemotherapyElemental dietEsophageal cancerGlutamineMucositis

Identifiers

PMID26266659
PMCPMC4689762
OpenAlexW2121997222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.