ArticleJournal of diabetes research2015
Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks.
Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The effect of acute cocoa flavanol intake on the BOLD response and cognitive function in type 1 diabetes: a randomized, placebo-controlled, double-blinded cross-over pilot study.Psychopharmacology · 2019Trial
- Exploratory Multisite MR Spectroscopic Imaging Shows White Matter Neuroaxonal Loss Associated with Complications of Type 1 Diabetes in Children.AJNR. American journal of neuroradiology · 2023Article
- Hypothalamic inflammation in metabolic disorders and aging.Cellular and molecular life sciences : CMLS · 2021Review
- Functional Magnetic Resonance Imaging Findings in Children and Adolescents With Chronic Kidney Disease: Preliminary Findings.Seminars in nephrology · 2021Review
- Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory.Diabetes · 2020Article
- Executive task-based brain function in children with type 1 diabetes: An observational study.PLoS medicine · 2019Observational
- The impact of type 1 diabetes on neural activity serving attention.Human brain mapping · 2019Article
- Basal ganglia cerebral blood flow associates with psychomotor speed in adults with type 1 diabetes.Brain imaging and behavior · 2018Article
- Neurophysiological Evidence for a Compensatory Activity during a Simple Oddball Task in Adolescents with Type 1 Diabetes Mellitus.Journal of diabetes research · 2018Article
- Complex systems representing effective connectivity in patients with Type One diabetes mellitus.PloS one · 2018Article
- Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes.Diabetes · 2017Article
- Effect of verbal task complexity in a working memory paradigm in patients with type 1 diabetes. A fMRI study.PloS one · 2017Article
- Brain Activation and Psychomotor Speed in Middle-Aged Patients with Type 1 Diabetes: Relationships with Hyperglycemia and Brain Small Vessel Disease.Journal of diabetes research · 2016Article
- Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review.Frontiers in human neuroscience · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1D versus healthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.
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