ArticleJournal of clinical and diagnostic research : JCDR2015
Prevalence of MLSB Resistance and Observation of erm A & erm C Genes At A Tertiary Care Hospital.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Nasal Carriage of Methicillin-ResistantInterdisciplinary perspectives on infectious diseases · 2025Article
- A Small Multihost Plasmid CarryingFrontiers in veterinary science · 2022Article
- Inducible Clindamycin Resistant Staphylococcus aureus among Patients Attending Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
- Nasal Carriage of Methicillin-ResistantInternational journal of microbiology · 2021Article
- Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.The Indian journal of medical research · 2019Review
- Phenotypic and genotypic characterization of macrolide, lincosamide and streptogramin B resistance among clinical isolates of staphylococci in southwest of Iran.BMC research notes · 2018Article
- Prevalence of methicillin resistant Staphylococcus aureus in Lumbini Medical College and Teaching Hospital, Palpa, Western Nepal.BMC research notes · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increasing resistance to macrolide, lincosamide, streptogramin B (MLSB) agents among Staphylococcus aureus is becoming a challenge to microbiologist. Clindamycin has been a useful drug for treatment of infection caused by the staphylococcus aureus, but change in clindamycin sensitivity pattern due to various mechanisms is leading to therapeutic failure. One of the important mechanisms is mediation of resistance by erm genes. Staphylococcus strains which have erm genes show inducible clindamycin resistance that cannot be determined by routine disk diffusion test resulting in treatment failure.
aimThis study was aimed to detect the prevalence of MLSBi and MLSBc resistance and observation of erm A & erm C genes among MLSBi isolates. MATERIALS AND
methodsA total 500 Staphylococcus aureus were isolated; they were checked by disk induction test (D- Test). Those isolates which showed inducible clindamycin resistance were randomly selected and subjected to PCR for the observation of erm A and erm C genes.
resultsPrevalence of MLSBi and MLSBc isolates were almost similar that is 10.8% and 11.6% respectively. MLSBi isolates showed more resistance to drugs when compared to MLSBc isolates. Neither of MLSBi and MLSBc isolates was resistant to Vancomycin and Linezolid. Inducible clindamycin was mainly due to presence of erm A gene.
conclusionD- test should be mandatory at every microbiology laboratory and should be used in routine antibiotic procedure which will minimize the misuse of drug ultimately minimize the risk of treatment failure. PCR should be performed for the detection of genes responsible for erythromycin resistance as it is a quick and most sensitive method.
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