Evidence map›Paper›PMID 26266119›Full record

ArticleJournal of clinical and diagnostic research : JCDR2015

Molecular Characterization and Resistant Spectrum of Enterococci Isolated from a Haematology Unit in China.

Jiajia Yu, Jinfang Shi, Ruike Zhao, Qingzhen Han, Xuefeng Qian, Guohao Gu, Xianfeng Zhang, Jie Xu

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Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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  2. Molecular Analysis ofArchives of Razi Institute · 2023
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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jiajia YuFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Jinfang ShiFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Ruike ZhaoFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Qingzhen HanFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Xuefeng QianFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Guohao GuFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Xianfeng ZhangFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .
Jie XuFaculty, Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University , Suzhou, P.R. of China .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe present study screened clinical isolates of E. faecalis and E. faecium to determine resistant spectrum and the potential virulence genes characterization among them of haematology patients.

methodsClinical Enterococci isolates were obtained from a haematology unit in a tertiary care hospital in China.

resultsAmong 125 isolates available for the investigation, 46 were identified as E. faecium, and 79 were E. faecalis. Urine was the most common source (82, 65.6%). E. faecium isolates were more resistant than E. faecalis. Among E. faecium, maximum resistance was seen against PEN 93.5% and AMP 93.5% followed by CIP 87%. Eight vancomycin-resistant E. faecium (VREfm) isolates were obtained, positive for vanA genotype. Of 125 Enterococci isolates, 67(53.6%) were acm, and 42.4%, 25.6%, 25.6%, 24.8%, 23.2%, 20.8%, 10.4% and 7.2% of isolates were positive for esp, cylL-A, asa 1, cylL-S, cpd, cylL-L, gel-E and ace, respectively. E. faecalis isolates have more virulence genes (VGs) than E. faecium. MLST analysis of VREfm identified three different STs (ST17, ST78 and ST203).

conclusionThe study provides the molecular characterization and resistant spectrum of Enterococci isolated from a haematology unit in China. Molecular analysis showed that all VREfm isolates belonged to pandemic clonal complex-17(CC17), associated with hospital-related isolates. Therefore, determining resistant spectrum and virulence characterization is crucial for the prevention and control of the spread of nosocomial infections caused by Enterococci in the haematology unit.

Indexed as

Molecular analysisNosocomial infectionsVancomycin-resistant Enterococci

Identifiers

PMID26266119
PMCPMC4525508

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