Evidence map›Paper›PMID 26266060›Full record

ArticleCase reports in gastrointestinal medicine2015

Cannabinoid Hyperemesis Syndrome: A Paradoxical Cannabis Effect.

Ivonne Marie Figueroa-Rivera, Rodolfo Estremera-Marcial, Marielly Sierra-Mercado, José Gutiérrez-Núñez, Doris H Toro

Abstract read
In one paragraph

Article in Case reports in gastrointestinal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment-a Systematic Review.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2017
    Pooled it
  3. Article
  4. Cannabis Hyperemesis Syndrome in Youth: Clinical Insights and Public Health Implications.International journal of environmental research and public health · 2025
    Review
  5. Cannabinoid Hyperemesis.Medical cannabis and cannabinoids · 2019
    Review
  6. Article
  7. Severity and outcomes of acute alcoholic pancreatitis in cannabis users.Translational gastroenterology and hepatology · 2017
    Article
  8. Cannabinoid hyperemesis syndrome.BMJ case reports · 2016
    Article
  9. Review
  10. Cannabis Hyperemesis Syndrome: What Do We Know?Medical cannabis and cannabinoids
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ivonne Marie Figueroa-RiveraInternal Medicine Program, Department of Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA.
Rodolfo Estremera-MarcialInternal Medicine Program, Department of Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA.
Marielly Sierra-MercadoInternal Medicine Program, Department of Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA.
José Gutiérrez-NúñezInternal Medicine Program, Department of Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA.
Doris H ToroDepartment of Gastroenterology, Veterans Affairs Caribbean Healthcare System, San Juan, PR 00921-3201, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite well-established antiemetic properties of marijuana, there has been increasing evidence of a paradoxical effect in the gastrointestinal tract and central nervous system, given rise to a new and underrecognized clinical entity called the Cannabinoid Hyperemesis Syndrome. Reported cases in the medical literature have established a series of patients exhibiting a classical triad of symptoms: cyclic vomiting, chronic marijuana use, and compulsive bathing. We present a case of a 29-year-old man whose clinical presentation strongly correlates with cannabinoid hyperemesis syndrome. Despite a diagnosis of exclusion, this syndrome should be considered plausible in the setting of a patient with recurrent intractable vomiting and a strong history of cannabis use as presented in this case.

Identifiers

PMID26266060
PMCPMC4525754

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.