ArticleNutrition & metabolism2015
High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
Article in Nutrition & metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Multiple time-dependent pathophysiological changes in a rabbit model of high-fat diet-induced hyperlipidemia.FEBS open bio · 2023Article
- Is apoCIII-Lowering A Double-Edged Sword?Journal of atherosclerosis and thrombosis · 2022Article
- Article
- Experimental Atherosclerosis Research on Large and Small Animal Models in Vascular Surgery.Journal of vascular research · 2022Review
- Diet-induced Alzheimer's-like syndrome in the rabbit.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Goji Berry (Animals : an open access journal from MDPI · 2021Article
- Research methods for animal models of atherosclerosis (Review).Molecular medicine reports · 2021Article
- High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index.Journal of public health research · 2021Article
- Study of Probiotic Effects ofBiology · 2021Article
- Hyperlipidaemia and cardioprotection: Animal models for translational studies.British journal of pharmacology · 2020Review
- Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke.Frontiers in neurology · 2020Article
- Animal models of human atherosclerosis: current progress.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Review
- Hypertriglyceridemia and Atherosclerosis: Using Human Research to Guide Mechanistic Studies in Animal Models.Frontiers in endocrinology · 2020Review
- Diet-Induced Rabbit Models for the Study of Metabolic Syndrome.Animals : an open access journal from MDPI · 2019Review
- Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives.International journal of molecular sciences · 2018Review
- An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment.Journal of visualized experiments : JoVE · 2018Article
- Principles and Applications of Rabbit Models for Atherosclerosis Research.Journal of atherosclerosis and thrombosis · 2018Review
- Insulin resistance in ischemic stroke.Metabolic brain disease · 2017Review
- Arterial Calcification in Diabetes Mellitus: Preclinical Models and Translational Implications.Arteriosclerosis, thrombosis, and vascular biology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis. Our aim in this study was to address whether diet-induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits.
methodsWe fed Watanabe heritable hyperlipidemic (WHHL) rabbits with a high-fructose and high-fat diet (HFFD) with restricted normal calories and compared the lesions of both aortic and coronary atherosclerosis with those of control WHHL rabbits fed a normal chow diet.
resultsHFFD-fed WHHL rabbits showed insulin resistance and impaired glucose tolerance accompanied by elevated plasma lipid levels and accumulation of adipose tissue even though their body weight was unchanged compared to the control rabbits. At 8 weeks, the aortic gross lesion area of HFFD-fed WHHL rabbits was increased by 40 % over the controls and their lesions were characterized by increased number of macrophages and smooth muscle cells. At 16 weeks, the lesions of HFFD-fed WHHL rabbits showed more advanced lesions such as lipid core formation and calcification. In addition, coronary atherosclerosis was significantly increased in HFFD-fed WHHL rabbits.
conclusionsThese results suggest that insulin resistance accelerates lesion formation of atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.