ArticlePhysiological reports2015
Seasonal variation in muscle sympathetic nerve activity.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03900832 (Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ambient Temperature and Cardiac Biomarkers: A Meta-Analysis.Current cardiology reviews · 2023Pooled it
- Association between ambient temperature and blood pressure in hypertensive adults in Bogor City, Indonesia: a 6-year longitudinal cohort study.Osong public health and research perspectives · 2026Article
- Diurnal temperature range and hypertension: cross-sectional and longitudinal findings from the China Health and Retirement Longitudinal Study (CHARLS).BMC public health · 2024Article
- Short-term association between outdoor temperature and the hydration-marker copeptin: a pooled analysis in five cohorts.EBioMedicine · 2023Article
- Exposure to air pollution and its effect on ischemic strokes (EP-PARTICLES study).Scientific reports · 2022Article
- Repeated warm water baths decrease sympathetic activity in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Morning blood pressure surge in early autosomal dominant polycystic kidney disease and its relation with left ventricular hypertrophy.Renal failure · 2021Article
- Moderate whole body heating attenuates the exercise pressor reflex responses in older humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Impact on Blood Pressure of a Short-Term Change in Indoor Temperature.International journal of general medicine · 2021Article
- Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Sympathetic responses induced by radiofrequency catheter ablation of atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2019Article
- Health effects of seasonal variation in cardiovascular hemodynamics among workers in forest environments.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment.Journal of physiological anthropology · 2018Article
- Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Passive heat therapy: a ready route to vascular health?The Journal of physiology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Epidemiologic data suggest there are seasonal variations in the incidence of severe cardiac events with peak levels being evident in the winter. Whether autonomic indices including muscle sympathetic nerve activity (MSNA) vary with season remains unclear. In this report, we tested the hypothesis that resting MSNA varies with the seasons of the year with peak levels evident in the winter. We analyzed the supine resting MSNA in 60 healthy subjects. Each subject was studied during two, three, or four seasons (total 237 visits). MSNA burst rate in the winter (21.0 ± 6.8 burst/min, mean ± SD) was significantly greater than in the summer (13.5 ± 5.8 burst/min, P < 0.001), the spring (17.1 ± 9.0 burst/min, P = 0.03), and the fall (17.9 ± 7.7 burst/min, P = 0.002). There was no significant difference in MSNA for other seasonal comparisons. The results suggest that resting sympathetic nerve activity varies along the seasons, with peak levels evident in the winter. We speculate that the seasonal changes in sympathetic activity may be a contribution to the previously observed seasonal variations in cardiovascular morbidity and mortality.
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