ArticlePhysiological reports2015
Systemic adaptation of lipid metabolism in response to low- and high-fat diet in Nile tilapia (Oreochromis niloticus).
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 146 citations in OpenAlex.
- Pre-winter feeding high-fat diet with caffeic acid phenethyl ester attenuates weight loss and improves health and muscle quality in grass carp during overwintering.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Fatty Acid Profiles in Tissues of Japanese Eel (Animals : an open access journal from MDPI · 2026Article
- Knockout of bsal/cel.2 results in growth retardation, reduced lipid digestion and altered energy metabolism in medaka larvae (oryzias latipes).Functional & integrative genomics · 2026Article
- Effects of Brazilian Pepper Tree (Biology · 2026Article
- Diet-Induced Modulation of Gut Microbiota Affects Meat Quality in Grass Carp (Microorganisms · 2026Article
- Evaluation of Propylene Glycol and Essential Oil Supplementation on Growth Performance, Feed Efficiency, Serum Biochemical Indices, Hematological Parameters, and the Expression of Antifreeze IV and Lipid Metabolism-Related Genes in Nile Tilapia.Animals : an open access journal from MDPI · 2026Article
- Fatty Liver in Fish: Metabolic Drivers, Molecular Pathways and Physiological Solutions.Animals : an open access journal from MDPI · 2026Review
- EPI-DOM framework for assessing fish welfare: external and internal indicators for tilapia.Frontiers in veterinary science · 2026Article
- Dietary Bile Acid Influences the Physiological, Morphological, Lipid Metabolism-Related Responses, and Transcriptomic Profile of Hepatopancreas in High-Fat Diet-Fed Juvenile Gibel Carp (Animals : an open access journal from MDPI · 2025Article
- Caffeic acid phenethyl ester improves high-carbohydrate diet utilization by promoting adipocyte hyperplasia in grass carp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Nutritional and physiological effects of high-fat diets in finfish: effects on growth, immunity, lipid metabolism, and intestinal health: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Review
- Adipocyte Hyperplasia Facilitated Adipose Tissue Expansion to Alleviate Hepatopancreas Injury in Nile Tilapia (Aquaculture nutrition · 2025Article
- Gut MicrobeAquaculture nutrition · 2025Article
- Tissue-Specific Mechanism of Fat Distribution in Teleosts: Comparative Analysis Between Two Carnivorous Marine Species, Golden Pompano (Aquaculture nutrition · 2025Article
- Temperature and feeding frequency: interactions with growth, immune response, and water quality in juvenile Nile tilapia.BMC veterinary research · 2024Article
- Dietary Chitosan Attenuates High-Fat Diet-Induced Oxidative Stress, Apoptosis, and Inflammation in Nile Tilapia (Biology · 2024Article
- Enhancing growth, liver health, and bile acid metabolism of tilapia (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Antioxidants (Basel, Switzerland) · 2024Article
- Differences in diacylglycerol acyltransferases expression patterns and regulation cause distinct hepatic triglyceride deposition in fish.Communications biology · 2024Article
- Dietary L-carnitine supplementation changes lipid metabolism and glucose utilization of Rhynchocypris lagowskii fed diets with different lipid sources.Fish physiology and biochemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural selection endows animals with the abilities to store lipid when food is abundant and to synthesize lipid when it is limited. However, the relevant adaptive strategy of lipid metabolism has not been clearly elucidated in fish. This study examined the systemic metabolic strategies of Nile tilapia to maintain lipid homeostasis when fed with low- or high-fat diets. Three diets with different lipid contents (1%, 7%, and 13%) were formulated and fed to tilapias for 10 weeks. At the end of the feeding trial, the growth rate, hepatic somatic index, and the triglyceride (TG) contents of serum, liver, muscle, and adipose tissue were comparable among three groups, whereas the total body lipid contents and the mass of adipose tissue increased with the increased dietary lipid levels. Overall quantitative PCR, western blotting and transcriptomic assays indicated that the liver was the primary responding organ to low-fat (LF) diet feeding, and the elevated glycolysis and accelerated biosynthesis of fatty acids (FA) in the liver is likely to be the main strategies of tilapia toward LF intake. In contrast, excess ingested lipid was preferentially stored in adipose tissue through increasing the capability of FA uptake and TG synthesis. Increasing numbers, but not enlarging size, of adipocytes may be the main strategy of Nile tilapia responding to continuous high-fat (HF) diet feeding. This is the first study illuminating the systemic adaptation of lipid metabolism responding to LF or HF diet in fish, and our results shed new light on fish physiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.