Evidence map›Paper›PMID 26265746›Full record

ArticlePhysiological reports2015

Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: effects on blood pressure, arrhythmias, and ventricular electrophysiology.

Elizabeth M Annoni, Xueyi Xie, Steven W Lee, Imad Libbus, Bruce H KenKnight, John W Osborn, Elena G Tolkacheva

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04768738 (The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters In Healthy Young Individuals), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04768738 nacompletednot on this mapstarted 2020, after this paper: background citation

The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters In Healthy Young Individuals: Randomized, Double-Blind Study

TypeinterventionalSponsorSinop UniversityRan2020 to 2020Enrolled46ConditionsHealthy, Activity, MotorArmsAuricular Vagus Nerve Stimulation Level Of Above Threshold, Auricular Vagus Nerve Stimulation Level Of Subthreshold, Auricular Vagus Nerve Stimulation Sham Method, 5 Minutes Bicycle Exercise
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 55 citations in OpenAlex.

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  12. Vagus Nerve Stimulation and the Cardiovascular System.Cold Spring Harbor perspectives in medicine · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth M AnnoniDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Xueyi XieDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Steven W LeeDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Imad LibbusCyberonics Inc., Houston, TX, USA.
Bruce H KenKnightDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA Cyberonics Inc., Houston, TX, USA.
John W OsbornDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.
Elena G TolkachevaDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA talkacal@umn.edu.
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension (HTN) is the single greatest risk factor for potentially fatal cardiovascular diseases. One cause of HTN is inappropriately increased sympathetic nervous system activity, suggesting that restoring the autonomic nervous balance may be an effective means of HTN treatment. Here, we studied the potential of vagus nerve stimulation (VNS) to treat chronic HTN and cardiac arrhythmias through stimulation of the right cervical vagus nerve in hypertensive rats. Dahl salt-sensitive rats (n = 12) were given a high salt diet to induce HTN. After 6 weeks, rats were randomized into two groups: HTN-Sham and HTN-VNS, in which VNS was provided to HTN-VNS group for 4 weeks. In vivo blood pressure and electrocardiogram activities were monitored continuously by an implantable telemetry system. After 10 weeks, rats were euthanized and their hearts were extracted for ex vivo electrophysiological studies using high-resolution optical mapping. Six weeks of high salt diet significantly increased both mean arterial pressure (MAP) and pulse pressure, demonstrating successful induction of HTN in all rats. After 4 weeks of VNS treatment, the increase in MAP and the number of arrhythmia episodes in HTN-VNS rats was significantly attenuated when compared to those observed in HTN-Sham rats. VNS treatment also induced changes in electrophysiological properties of the heart, such as reduction in action potential duration (APD) during rapid drive pacing, slope of APD restitution, spatial dispersion of APD, and increase in conduction velocity of impulse propagation. Overall, these results provide further evidence for the therapeutic efficacy of VNS in HTN and HTN-related heart diseases.

Indexed as

Arrhythmiahypertensionoptical mappingvagus nerve stimulation

Identifiers

PMID26265746
PMCPMC4562562
OpenAlexW2099476116

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.