Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Antihypertensive Use and Recurrent Falls in Community-Dwelling Older Adults: Findings From the Health ABC Study.
Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Hypertension Treatment in Frail Older Adults: A Systematic Review and Appraisal of Guidelines.Drugs & aging · 2023Pooled it
- Evidence synthesis based on non-randomised studies-a critical review of studies leading to conclusions on fall risk properties of loop diuretics/beta-blockers.European journal of clinical pharmacology · 2019Pooled it
- The Pharmacological Treatment of Arterial Hypertension in Frail, Older Patients—a Systematic ReviewDeutsches Arzteblatt international · 2019Pooled it
- A Systematic Review and Meta-Analyses of the Association Between Anti-Hypertensive Classes and the Risk of Falls Among Older Adults.Drugs & aging · 2018Pooled it
- Usage of Loop Diuretics for Hypertension is Associated With Increased Complications Following Total Hip Arthroplasty.Arthroplasty today · 2026Article
- Factors associated with fall risk increasing drug use in older black and white men and women: the Health ABC Study.BMC geriatrics · 2024Article
- Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults.Journal of the American Heart Association · 2024Article
- Association of low blood pressure and falls: An analysis of data from the Leiden 85-plus Study.PloS one · 2023Article
- Predictors of poor medication adherence of older people with hypertension.Nursing open · 2022Article
- Risk of Fall-Related Injuries Associated with Antidepressant Use in Elderly Patients: A Nationwide Matched Cohort Study.International journal of environmental research and public health · 2022Article
- Persistent polypharmacy and fall injury risk: the Health, Aging and Body Composition Study.BMC geriatrics · 2021Article
- Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study.Calcified tissue international · 2021Article
- Hypertension Management in Nursing Homes: Review of Evidence and Considerations for Care.Current hypertension reports · 2020Review
- Cardiac Rehabilitation to Optimize Medication Regimens in Heart Failure.Clinics in geriatric medicine · 2019Review
- The Relationships Between Physical Performance, Activity Levels, and Falls in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Article
- Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study.European journal of ageing · 2018Article
- Prescribing and deprescribing antihypertensive medication in older people by Dutch general practitioners: a qualitative study.BMJ open · 2018Article
- Deprescribing in Older Nursing Home Patients: Focus on Innovative Composite Measures for Dosage Deintensification.Innovation in aging · 2017Review
- Stroke and Falls-Clash of the Two Titans in Geriatrics.Geriatrics (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundDespite wide-spread use of antihypertensives in older adults, the literature is unclear about their association with incident recurrent falls over time.
methodsHealth, Aging and Body Composition study participants (n = 2,948) who were well functioning at baseline (1997) were followed to Year 7 (2004). The main outcome was recurrent falls (≥2) in the ensuing 12 months. Antihypertensive use was examined as: (a) any versus none, (b) long- versus short-term (≥2 vs <2 years), and by (c) summated standardized daily dose (SDD; 1 = maximum recommended daily dose for one antihypertensive), and (d) subclass.
resultsControlling for potential demographic, health status/behavior and access to care confounders, we found no increase in risk of recurrent falls in antihypertensive users compared to nonusers (adjusted odds ratio [AOR] = 1.13; 95% CI = 0.88-1.46), or those taking higher SDDs or for longer durations. Only those using a loop diuretic were found to have a modest increased risk of recurrent falls (AOR = 1.50; 95% CI = 1.11-2.03).
conclusionsAntihypertensive use overall was not statistically significantly associated with recurrent falls after adjusting for important confounders. Loop diuretic use may be associated with recurrent falls and needs further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.