ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Tequila Regulates Insulin-Like Signaling and Extends Life Span in Drosophila melanogaster.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Sex-Specific Neuropsychiatric Effects of Subanesthetic Ketamine Exposure in Pregnant Mice and Their Offspring.Cellular and molecular neurobiology · 2025Article
- An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan.PLoS genetics · 2025Article
- Article
- Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis.Aging cell · 2021Article
- Impact of Probiotic Combination inMicroorganisms · 2020Article
- Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity.Aging cell · 2019Article
- Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.PLoS biology · 2019Article
- Article
- Conserved Transcription Factors Steer Growth-Related Genomic Programs in Daphnia.Genome biology and evolution · 2017Article
- α-amanitin resistance in Drosophila melanogaster: A genome-wide association approach.PloS one · 2017Article
- Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster.BMC genomics · 2016Article
- Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
The aging process is a universal phenomenon shared by all living organisms. The identification of longevity genes is important in that the study of these genes is likely to yield significant insights into human senescence. In this study, we have identified Tequila as a novel candidate gene involved in the regulation of longevity in Drosophila melanogaster. We have found that a hypomorphic mutation of Tequila (Teq(f01792)), as well as cell-specific downregulation of Tequila in insulin-producing neurons of the fly, significantly extends life span. Tequila deficiency-induced life-span extension is likely to be associated with reduced insulin-like signaling, because Tequila mutant flies display several common phenotypes of insulin dysregulation, including reduced circulating Drosophila insulin-like peptide 2 (Dilp2), reduced Akt phosphorylation, reduced body size, and altered glucose homeostasis. These observations suggest that Tequila may confer life-span extension by acting as a modulator of Drosophila insulin-like signaling.
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Registered trials
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