ReviewWiley interdisciplinary reviews. Developmental biology
Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics.
Review in Wiley interdisciplinary reviews. Developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Modeling developmental spiking behavior driven by ionic current dynamics of mouse and human inner hair cells using a calcium-enhanced Izhikevich framework.Journal of computational neuroscience · 2026Article
- CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception.Neuroscience letters · 2026Article
- TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development.Communications biology · 2024Article
- Identification of multiple transcription factor genes potentially involved in the development of electrosensoryFrontiers in cell and developmental biology · 2024Article
- Protein phosphatase 1 regulates core PCP signaling.EMBO reports · 2023Article
- Spontaneous allelic variant in deafness-blindness gene Ush1g resulting in an expanded phenotype.Genes, brain, and behavior · 2023Article
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Vangl as a Master Scaffold for Wnt/Planar Cell Polarity Signaling in Development and Disease.Frontiers in cell and developmental biology · 2022Review
- Actin Crosslinking Family Protein 7 Deficiency Does Not Impair Hearing in Young Mice.Frontiers in cell and developmental biology · 2021Article
- Rab11a Regulates the Development of Cilia and Establishment of Planar Cell Polarity in Mammalian Vestibular Hair Cells.Frontiers in molecular neuroscience · 2021Article
- Article
- Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands.Developmental cell · 2020Article
- Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells.iScience · 2020Article
- Convergent extension in mammalian morphogenesis.Seminars in cell & developmental biology · 2020Review
- Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.Cold Spring Harbor perspectives in medicine · 2020Review
- New insights into regulation and function of planar polarity in the inner ear.Neuroscience letters · 2019Review
- Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity.Current biology : CB · 2019Article
- Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organization.Cell death & disease · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hearing loss is the most common and costly sensory defect in humans and genetic causes underlie a significant proportion of affected individuals. In mammals, sound is detected by hair cells (HCs) housed in the cochlea of the inner ear, whose function depends on a highly specialized mechanotransduction organelle, the hair bundle. Understanding the factors that regulate the development and functional maturation of the hair bundle is crucial for understanding the pathophysiology of human deafness. Genetic analysis of deafness genes in animal models, together with complementary forward genetic screens and conditional knock-out mutations in essential genes, have provided great insights into the molecular machinery underpinning hair-bundle development and function. In this review, we highlight recent advances in our understanding of hair-bundle morphogenesis, with an emphasis on the molecular pathways governing hair-bundle polarity and orientation. We next discuss the proteins and structural elements important for hair-cell mechanotransduction as well as hair-bundle cohesion and maintenance. In addition, developmental signals thought to regulate tonotopic features of HCs are introduced. Finally, novel approaches that complement classic genetics for studying the molecular etiology of human deafness are presented. WIREs Dev Biol 2016, 5:85-101. doi: 10.1002/wdev.202 For further resources related to this article, please visit the WIREs website.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.