Evidence map›Paper›PMID 26265460›Full record

ArticleAnnals of biomedical engineering2016

Hydraulic Conductivity of Smooth Muscle Cell-Initiated Arterial Cocultures.

Rishi A Mathura, Sparkle Russell-Puleri, Limary M Cancel, John M Tarbell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rishi A MathuraDepartment of Biomedical Engineering, The City College of New York, New York, NY, 10031, USA.
Sparkle Russell-PuleriDepartment of Biomedical Engineering, The City College of New York, New York, NY, 10031, USA.
Limary M CancelDepartment of Biomedical Engineering, The City College of New York, New York, NY, 10031, USA.
John M TarbellDepartment of Biomedical Engineering, The City College of New York, New York, NY, 10031, USA. tarbell@ccny.cuny.edu.
City College of New York · US

Funding

SHEAR STRESS EFFECTS ON ENDOTHELIAL TRANSPORTR01HL057093 · NHLBI · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI TARBELL, JOHN M · 1997 to 2010
$2.7M
NHLBI NIH HHS HL57093NHLBI NIH HHS R01 HL057093
6 · The paper itself

Abstract

The purpose of the study was to examine the effects of arterial coculture conditions on the transport properties of several in vitro endothelial cell (EC)-smooth muscle cell (SMC)-porous filter constructs in which SMC were grown to confluence first and then EC were inoculated. This order of culturing simulates the environment of a blood vessel wall after endothelial layer damage due to stenting, vascular grafting or other vascular wall insult. For all coculture configurations examined, we observed that hydraulic conductivity (L(p)) values were significantly higher than predicted by a resistances-in-series (RIS) model accounting for the L(p) of EC and SMC measured separately. The greatest increases were observed when EC were plated directly on top of a confluent SMC layer without an intervening filter, presumably mediated by direct EC-SMC contacts that were observed under confocal microscopy. The results are the opposite of a previous study that showed L(p) was significantly reduced compared to an RIS model when EC were grown to confluency first. The physiological, pathophysiological and tissue engineering implications of these results are discussed.

Indexed as

Models, CardiovascularAnimalsArteriesCattleCells, CulturedEndothelial CellsMechanotransduction, CellularMuscle, Smooth, VascularMyocytes, Smooth MuscleCocultureEndothelial cellsHydraulic conductivityPorous membraneSmooth muscle cells

Identifiers

PMID26265460
PMCPMC4752435
OpenAlexW1163583133

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.