ArticleGeneral hospital psychiatry
Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C.
Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Development and Preliminary Evaluation of an Integrated Cognitive-Behavior Treatment for Chronic Pain and Substance Use Disorder in Patients with the Hepatitis C Virus.Pain medicine (Malden, Mass.) · 2016Trial
- Prescription Opioid Misuse, Pain Interference, Resilience, and Anxiety Among Chinese People Living with HIV: A Moderated Mediation Model.AIDS and behavior · 2023Article
- Depression explains the association between pain intensity and pain interference among adults with neurofibromatosis.Journal of neuro-oncology · 2021Article
- Characterising the association between positive hepatitis C virus antibody and pain among people who inject drugs.Drug and alcohol review · 2019Article
- A Survey on the Prevalence of Depression in Blood Donors with Hepatitis C in Shiraz.Hepatitis monthly · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveDepression and chronic pain are common in persons chronically infected with the hepatitis C virus (HCV), although little is known about the rate of co-occurrence or mechanisms by which they are associated. We evaluated whether pain-related anxiety mediates the relationship between depressive symptoms and pain-related physical functioning in patients with HCV.
methodsPatients with HCV (n=175) completed self-report measures assessing demographic characteristics, pain-related function and mental health. Path analyses examined direct effects of cognitive-affective and somatic symptoms of depression on pain interference and indirect effects of these relationships via four subscales of the Pain Anxiety Symptoms Scale-20.
resultsCognitive-affective and somatic symptoms of depression were positively and significantly related to pain interference. Pain-related anxiety mediated the relationship between both cognitive-affective and somatic symptoms of depression, and this mediation was predominantly accounted for by the escape-avoidance component of pain-related anxiety.
conclusionsFindings indicate a potential mediating role of pain-related anxiety, particularly escape-avoidance anxiety, on the relationship between depression and pain interference in patients with HCV. These findings suggest that escape-avoidance anxiety may be a particularly germane target for treatment in patients with HCV and chronic pain, particularly when depression, with characteristic features of withdrawal and inhibition, is a comorbid condition.
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