ArticleEuropean archives of psychiatry and clinical neuroscience2016
Altered functional connectivity density in major depressive disorder at rest.
Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- A Study of the Brain Functional Network of Post-Stroke Depression in Three Different Lesion Locations.Scientific reports · 2017Trial
- Exploring the correlation between childhood trauma experiences, inflammation, and brain activity in first-episode, drug-naive major depressive disorder.European archives of psychiatry and clinical neuroscience · 2025Article
- Abnormalities of regional brain activity in patients with asymptomatic internal carotid artery occlusion: a resting-state fMRI study.BMC neurology · 2025Article
- The relationship between regional homogeneity in resting-state functional magnetic resonance imaging and cognitive function in depressive disorders with migraine.Scientific reports · 2025Article
- Adaptive Whole-Brain Dynamics Predictive Method: Relevancy to Mental Disorders.Research (Washington, D.C.) · 2025Article
- Functional connectivity density of different suicidal behaviors in adolescents with major depressive disorders.Frontiers in psychiatry · 2024Article
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- Abnormal functional connectivity density involvement in freezing of gait and its application for subtyping Parkinson's disease.Brain imaging and behavior · 2023Article
- Frequency specificity of aberrant triple networks in major depressive disorder: a resting-state effective connectivity study.Frontiers in neuroscience · 2023Article
- Distinct profiles of functional connectivity density aberrance in Alzheimer's disease and mild cognitive impairment.Frontiers in psychiatry · 2022Article
- Gender differences in major depressive disorders: A resting state fMRI study.Frontiers in psychiatry · 2022Article
- The functional connectivity of the middle frontal cortex predicts ketamine's outcome in major depressive disorder.Frontiers in neuroscience · 2022Article
- Functional MRI Changes in Patients after Thyroidectomy under General Anesthesia.BioMed research international · 2022Article
- Differential Abnormality in Functional Connectivity Density in Preclinical and Early-Stage Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia.Neuropsychiatric disease and treatment · 2022Article
- Common and distinct brain functional alterations in pharmacotherapy treatment-naïve female borderline personality disorder patients with and without auditory verbal hallucinations: a pilot study.European archives of psychiatry and clinical neuroscience · 2021Article
- Improved Pre-attentive Processing With Occipital rTMS Treatment in Major Depressive Disorder Patients Revealed by MMN.Frontiers in human neuroscience · 2021Article
- Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes.Brain imaging and behavior · 2020Article
- Differences in functional connectivity density among subtypes of schizophrenic auditory hallucination.Brain imaging and behavior · 2020Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder is characterized by abnormal brain connectivity at rest. Currently, most studies investigating resting-state activity rely on a priori restrictions on specific networks or seed regions, which may bias observations. We hence sought to elicit functional alterations in a hypothesis-free approach. We applied functional connectivity density (FCD) to identify abnormal connectivity for each voxel in the whole brain separately. Comparing resting-state fMRI in 21 MDD patients and 23 matched healthy controls, we identified atypical connections for regions exhibiting abnormal FCD and compared our results to those of an independent component analysis (ICA) on networks previously investigated in MDD. Patients showed reduced FCD in mid-cingulate cortex (MCC) and increased FCD in occipital cortex (OCC). These changes in global FCD were driven by abnormal local connectivity changes and reduced functional connectivity (FC) toward the left amygdala for MCC, and increased FC toward the right supplementary motor area for OCC. The altered connectivity was not reflected in ICA comparison of the salience and visual networks. Abnormal FC in MDD is present in cingulate and OCC in terms of global FCD. This converges with previous structural and metabolic findings; however, these particular changes in connectivity would not have been identified using canonical seed regions or networks. This implies the importance of FC measures in the investigation of brain pathophysiology in depression.
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