Evidence map›Paper›PMID 26264969›Full record

ArticleVirology2015

Downregulation of key regulatory proteins in androgen dependent prostate tumor cells by oncolytic reovirus.

Pooja Gupta-Saraf, Tyler Meseke, Cathy L Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pooja Gupta-SarafDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 , United States; Interdepartmental Genetics Program, Iowa State University, Ames, IA 50011, United States. Electronic address: pgupta@iastate.edu.
Tyler MesekeDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 , United States; Biology Program, Iowa State University, Ames, IA 50011, United States. Electronic address: tmeseke@iastate.edu.
Cathy L MillerDepartment of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 , United States; Interdepartmental Genetics Program, Iowa State University, Ames, IA 50011, United States; Biology Program, Iowa State University, Ames, IA 50011, United States. Electronic address: clm@iastate.edu.
Iowa State University · US

Funding

Virus and cell regulation of reovirus escape from translation inhibitionR15AI090635 · NIAID · IOWA STATE UNIVERSITY · PI MILLER, CATHY L · 2010 to 2010
$431k
NIAID NIH HHS R15 AI090635NIAID NIH HHS R15AI090635
6 · The paper itself

Abstract

As prostate tumor cell growth depends on hormones, androgen ablation is an effective therapy for prostate cancer (PCa). However, progression of PCa cells to androgen independent growth (castrate resistant prostate cancer, CRPC) results in relapse and mortality. Hypoxia, a microenvironment of low oxygen that modifies the activity of PCa regulatory proteins including the androgen receptor (AR), plays a critical role in progression to CRPC. Therapies targeting hypoxia and the AR may lengthen the time to CRPC progression thereby increasing survival time of PCa patients. Mammalian Orthoreovirus (MRV) has shown promise for the treatment of prostate tumors in vitro and in vivo. In this study, we found that MRV infection induces downregulation of proteins implicated in CRPC progression, interferes with hypoxia-induced AR activity, and induces apoptosis in androgen dependent cells. This suggests MRV possesses traits that could be exploited to create novel therapies for the inhibition of progression to CRPC.

Indexed as

Gene Expression Regulation, NeoplasticAndrogensApoptosisCell HypoxiaCell Line, TumorHumansKallikreinsMaleOncolytic VirotherapyOncolytic VirusesOrthoreovirus, MammalianProstateProstate-Specific AntigenProto-Oncogene Proteins c-aktReceptors, AndrogenSignal TransductionAndrogensAR protein, humanKallikreinsKLK3 protein, humanProstate-Specific AntigenProto-Oncogene Proteins c-aktReceptors, AndrogenAktAndrogen receptorHypoxiaProstate cancerPSAReovirus

Identifiers

PMID26264969
PMCPMC4619118
OpenAlexW1058503913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.