ArticleSchizophrenia bulletin2015
A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurostructural, Neurofunctional, and Clinical Features of Chronic, Untreated Schizophrenia: A Narrative Review.Schizophrenia bulletin · 2025Pooled it
- Schizophrenia and Neurodevelopment: Insights From Connectome Perspective.Schizophrenia bulletin · 2025Review
- The Psychosis MRI Shared Data Resource (Psy-ShareD).Human brain mapping · 2025Article
- Acquired Pedophilia: international Delphi-method-based consensus guidelines.Translational psychiatry · 2023Review
- Cortical changes in patients with schizophrenia across two ethnic backgrounds.Scientific reports · 2022Article
- The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis.Schizophrenia bulletin open · 2022Article
- Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity.NPJ schizophrenia · 2021Article
- Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis.Psychological medicine · 2021Article
- Translational Application of a Neuro-Scientific Multi-Modal Approach Into Forensic Psychiatric Evaluation: Why and How?Frontiers in psychiatry · 2021Article
- In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia.Biomolecules · 2020Review
- Using Machine Learning and Structural Neuroimaging to Detect First Episode Psychosis: Reconsidering the Evidence.Schizophrenia bulletin · 2020Article
- Diverse definitions of the early course of schizophrenia-a targeted literature review.NPJ schizophrenia · 2018Review
- Psychiatric polygenic risk associates with cortical morphology and functional organization in aging.Translational psychiatry · 2017Article
- Sex disparities in substance abuse research: Evaluating 23 years of structural neuroimaging studies.Drug and alcohol dependence · 2017Review
- Diffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population.Translational psychiatry · 2016Article
- Free Energy and Virtual Reality in Neuroscience and Psychoanalysis: A Complexity Theory of Dreaming and Mental Disorder.Frontiers in psychology · 2016Article
- Article
- A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology.Diagnostic and interventional radiology (Ankara, Turkey)Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Resonance Imaging to investigate neuroanatomy in 126 patients with first episode schizophrenia who came from 4 ethnically distinct cohorts (White Caucasians, African-Caribbeans, Japanese, and Chinese). Each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year). We report a reduction in the gray matter volume of the right anterior insula in patients relative to controls (P < .05 corrected); this reduction was detected in all 4 ethnic groups despite differences in psychopathology, exposure to antipsychotic medication and image acquisition sequence. This finding provides evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic variations in incidence and clinical expression. In light of the existing literature, implicating the right anterior insula in bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety, we speculate that the neuroanatomical deficit reported here may represent a transdiagnostic feature of Axis I disorders.
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