ArticleInternational journal of obesity (2005)2016
Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Cardiometabolic risk factors in South American children: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Daily vitamin DEuropean journal of nutrition · 2021Trial
- The "Burden" of Childhood Obesity on Bone Health: A Look at Prevention and Treatment.Nutrients · 2025Review
- Serum vitamin D and obesity among US adolescents, NHANES 2011-2018.Frontiers in pediatrics · 2024Article
- Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche.Epigenetics · 2023Article
- Decreased vitamin D levels in the pediatric population after COVID-19 lockdown.Italian journal of pediatrics · 2023Article
- Multicentric Italian case-control study on 25OH vitamin D levels in children and adolescents with Prader-Willi syndrome.Journal of endocrinological investigation · 2023Article
- Patterns of 25-Hydroxyvitamin D3, Calcium Status, and Anemia in the Saudi Population: A Cross-Sectional Study.Life (Basel, Switzerland) · 2022Article
- Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.Environment international · 2022Article
- Higher latitude and lower solar radiation influence on hip fracture admissions in Chilean older population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- The Association Between Breast Density and Gut Microbiota Composition at 2 Years Post-Menarche: A Cross-Sectional Study of Adolescents in Santiago, Chile.Frontiers in cellular and infection microbiology · 2021Article
- Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche.Breast cancer research : BCR · 2020Article
- Common mechanisms for type 2 diabetes and psychosis: Findings from a prospective birth cohort.Schizophrenia research · 2020Article
- Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children.Public health nutrition · 2020Article
- Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents.Nutrients · 2019Article
- Obesity and hypovitaminosis D: causality or casualty?International journal of obesity supplements · 2019Review
- Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls.Clinical epigenetics · 2018Article
- High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study.Nutrients · 2018Observational
- 25OH vitamin D levels in pediatric patients affected by Prader-Willi syndrome.Journal of endocrinological investigation · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsistent data on the relation between vitamin D, body fat and insulin resistance (IR) in children are lacking.
objectives(1) To evaluate the association between serum 25-Hydroxyvitamin D [25(OH)D] and key indicators of: adiposity (total and central), IR, and (2) to estimate serum 25(OH)D cut-offs that best reflect IR and total and central adiposity in children. SUBJECTS/
methodsPrepubertal children (n=435, ~53% girls; ~age 7 years) from the Growth and Obesity Chilean Cohort Study were evaluated for potential associations between serum 25(OH)D and indicators of: (1) total adiposity (body mass index by age (BAZ), body fat (including three-component model)), central adiposity (waist circumference and trunk fatness); (2) IR (homeostasis model assessment of IR) and insulin sensitive (quantitative insulin sensitivity check index) using standardized multiple regression models with standardized coefficients and receiver operating characteristic curves.
resultsOverall, mean serum 25(OH)D was 32.1±9.2 ng ml(-1), while 19.4% of children were obese (BAZ⩾2 s.d.). Serum 25(OH)D was inversely associated with indicators of total and central adiposity and with IR indicators. Effect sizes were moderate in girls (~0.3 for adiposity and IR indicators), while, weaker values were found in boys. Serum 25(OH)D estimated cut-offs that best predicted total, central adiposity and IR were~30 ng ml(-1). Children with suboptimal serum 25(OH)D (<30 ng ml(-1)) had a higher risk (two to three times) of being obese (high BAZ, body fat percent and/or central adiposity); and three to four times greater risk for IR.
conclusionsSerum 25(OH)D was inversely associated with adiposity (total and central) and IR indicators in prepubertal Chilean children. The conventional cut-off of vitamin D sufficiency (⩾30 ng ml(-1)) was adequate to assess obesity and IR risk in this age group.
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