ArticleBMC pulmonary medicine2015
Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study.
Article in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The burden of autoimmune pulmonary alveolar proteinosis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Article
- Pulmonary nocardiosis in patients with underlying pulmonary alveolar proteinosis: a case series and review of the literature.BMC pulmonary medicine · 2026Review
- Secondary Pulmonary Alveolar Proteinosis Associated With Ruxolitinib After Bone-Marrow Transplantation: A Case With Transient Improvement Following Drug Discontinuation.Respirology case reports · 2026Article
- A Case of Autoimmune Pulmonary Alveolar Proteinosis.Clinical case reports · 2026Article
- Secondary Pulmonary Alveolar Proteinosis Complicated by Hemophagocytic Syndrome in a Patient with Adult-onset Still's disease: A Case-based Review.Internal medicine (Tokyo, Japan) · 2026Review
- Progressive Fibrosing Lung Disease Treated With Nintedanib in a Patient With Long-Standing Autoimmune Pulmonary Alveolar Proteinosis: A Case Report.Case reports in pulmonology · 2026Article
- Outcomes and outcome measures in studies of pulmonary alveolar proteinosis: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Serial Anti-GM-CSF Autoantibody Levels Reflect Disease Activity in Hypersensitivity Pneumonitis with Autoimmune Pulmonary Alveolar Proteinosis: Case Report.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Pulse Steroid Therapy for Severe Acute Respiratory Distress Syndrome: A Propensity Score-Matched Analysis.Journal of clinical medicine · 2025Article
- Diagnostic Dilemma in a Case of Anti-PL-7 Antibody-Positive Interstitial Lung Disease: When Autoimmune Alveolar Proteinosis Masquerades as Anti-Synthetase Syndrome.Respirology case reports · 2025Article
- Dyspnea and Deception: Overcoming Diagnostic Hurdles in Pulmonary Alveolar Proteinosis.Cureus · 2025Article
- The healthcare burden of pulmonary alveolar proteinosis (PAP).Orphanet journal of rare diseases · 2025Article
- Article
- Secondary Pulmonary Alveolar Proteinosis Development during the Treatment for Anti-aminoacyl-tRNA Synthetase Antibody-positive Interstitial Lung Disease.Internal medicine (Tokyo, Japan) · 2024Article
- Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report.Respirology case reports · 2024Article
- A case of autoimmune pulmonary alveolar proteinosis during the course of treatment of rapidly progressive interstitial pneumonia associated with anti-MDA5 antibody-positive dermatomyositis.BMC pulmonary medicine · 2024Article
- Article
- Pulmonary alveolar proteinosis following severe COVID - 19 infection: A case report.Respiratory medicine case reports · 2024Article
- Pulmonary alveolar proteinosis complicated by lung cancer with favorable prognosis: a case report and literature review.Frontiers in oncology · 2024Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough no report has demonstrated the efficacy of corticosteroid therapy for autoimmune pulmonary alveolar proteinosis (aPAP), we sometimes encounter patients who have received this therapy for various reasons. However, as corticosteroids can suppress alveolar macrophage function, corticosteroid therapy might worsen disease severity and increase the risk of infections.
methodsFor this retrospective cohort study, we sent a screening form to 165 institutions asking for information on aPAP patients treated with corticosteroids. Of the resulting 45 patients screened, 31 were enrolled in this study. We collected demographic data and information about corticosteroid treatment period, dose, disease severity score (DSS) over the treatment period, and complications.
resultsDSS deteriorated during corticosteroid therapy in 23 cases (74.1 %) and the estimated overall cumulative worsening rate was 80.8 % for the total observation period. The worsening rate was significantly higher in patients treated with high-dose prednisolone (>18.9 mg/day, n = 16) than treated with low-dose prednisolone (≤18.9 mg/day, n = 15) divided by median daily dose (p < 0.02). Of patients with worsening, one died of disseminated aspergillosis and another of respiratory failure. Infections newly emerged in 6 cases during corticosteroid therapy (p < 0.05). Median serum granulocyte/macrophage colony-stimulating factor (GM-CSF) autoantibody levels were similar to previously reported data in a large cohort study.
conclusionThe results demonstrate that corticosteroid therapy may worsen DSS of aPAP, increasing the risk for infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.