Evidence map›Paper›PMID 26264064›Full record

ArticleNeurocritical care2016

Therapeutic Hypothermia After Resuscitation From a Non-Shockable Rhythm Improves Outcomes in a Regionalized System of Cardiac Arrest Care.

Gene Sung, Nichole Bosson, Amy H Kaji, Mark Eckstein, David Shavelle, William J French, Joseph L Thomas, William Koenig, James T Niemann

Abstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. [Targeted temperature management for cardiac arrest with nonshockable rhythm].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020
    Article
  7. Resuscitating the Globally Ischemic Brain: TTM and Beyond.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  8. Article
  9. Observational
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Gene SungDepartment of Neurology, Keck School of Medicine of the University of Southern California, 1520 San Pablo St, Ste 3000, Los Angeles, CA, 90033, USA. gsung@usc.edu.
Nichole BossonDepartment of Emergency Medicine, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA, USA.
Amy H KajiDepartment of Emergency Medicine, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA, USA.
Mark EcksteinDepartment of Emergency Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
David ShavelleDepartment of Cardiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
William J FrenchDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Joseph L ThomasDavid Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
William KoenigLos Angeles County Emergency Medical Services Agency, Los Angeles, CA, USA.
James T NiemannDepartment of Emergency Medicine, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA, USA.
University of Southern California · USHarbor–UCLA Medical Center · USLos Angeles County Department of Health Services · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTherapeutic hypothermia (TH) improves neurologic outcome in patients resuscitated from ventricular fibrillation. The purpose of this study was to evaluate TH effects on neurologic outcome in patients resuscitated from a non-shockable out-of-hospital cardiac arrest rhythm. DESIGN AND

settingThis is a retrospective cohort study of data reported to a registry in an emergency medical system in a large metropolitan region. Patients achieving field return of spontaneous circulation are transported to designated hospitals with TH protocols. PATIENTS: Patients with an initial non-shockable rhythm were identified. Patients were excluded if awake in the Emergency Department or if TH was withheld due to preexisting coma or death prior to initiation. The decision to initiate TH was determined by the treating physician. MEASUREMENTS: The primary outcome was survival with good neurologic outcome defined by a cerebral performance category of 1 or 2. MAIN

resultsOf the 2772 patients treated for cardiac arrest during the study period, there were 1713 patients resuscitated from cardiac arrest with an initial non-shockable rhythm and 1432 patients met inclusion criteria. The median age was 69 years [IQR 59-82]; 802 (56%) male. TH was induced in 596 (42%) patients. Survival with good neurologic outcome was 14% in the group receiving TH, compared with 5% in those not treated with TH (risk difference = 8%, 95% CI 5-12%). The adjusted OR for a CPC 1 or 2 with TH was 2.9 (95% CI 1.9-4.4).

conclusionAnalyzing the data collected from the registry of the standard practice in a large metropolitan region, TH is associated with improved neurologic outcome in patients resuscitated from initial non-shockable rhythms in a regionalized system for post-resuscitation care.

Indexed as

Outcome Assessment, Health CareRegistriesAgedAged, 80 and overFemaleHumansHypothermia, InducedMaleMiddle AgedOut-of-Hospital Cardiac ArrestResuscitationRetrospective StudiesCardiac arrestResuscitationTherapeutic hypothermia

Identifiers

PMID26264064
OpenAlexW1185453458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.