ArticleInternational journal of colorectal disease2015
Quantification of autofluorescence imaging can accurately and objectively assess the severity of ulcerative colitis.
Article in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multimodal imaging as optical biopsy system for gastritis diagnosis in humans, and input of the mouse model.EBioMedicine · 2021Trial
- Autofluorescence and deep learning in early disease detection: biological foundations, clinical applications, and future directions.Frontiers in artificial intelligence · 2026Review
- Image enhanced colonoscopy: updates and prospects-a review.Translational gastroenterology and hepatology · 2023Review
- Endoscopic visualization of cancer and dysplasia in patients with ulcerative colitis following sensitization with oral 5-aminolevulinic acid.Journal of digestive diseases · 2020Article
- Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues.Molecules (Basel, Switzerland) · 2020Review
- Gastrointestinal diagnosis using non-white light imaging capsule endoscopy.Nature reviews. Gastroenterology & hepatology · 2019Review
- Modern Endoscopic Imaging in Diagnosis and Surveillance of Inflammatory Bowel Disease Patients.Gastroenterology research and practice · 2018Review
- The efficacy of autofluorescence imaging in the diagnosis of colorectal diseases.Clinical journal of gastroenterology · 2016Review
- Autofluorescence imaging endoscopy can distinguish non-erosive reflux disease from functional heartburn: A pilot study.World journal of gastroenterology · 2016Observational
- Mucosal Healing of Ulcerative Colitis Based on Endoscopic Diagnosis, Histopathology, and Mucosal Inflammatory Mediators.Inflammatory intestinal diseasesReview
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Authors and funding
18 authors.
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Abstract
BACKGROUND AND
aimsNo endoscopic examination has been able to evaluate severity of ulcerative colitis (UC) by quantification. This prospective study investigated the efficacy of quantifying autofluorescence imaging (AFI) to assess the severity of UC, which captures the fluorescence emitted from intestinal tissue and then quantifies the intensity using an image-analytical software program. MATERIALS AND
methodsEleven endoscopists separately evaluated 135 images of conventional endoscopy (CE) and AFI from a same lesion. A CE image corresponding to Mayo endoscopic subscore 0 or 1 was defined as being inactive. The fluorescence intensities of AFI were quantified using an image-analytical software program (F index; FI). Active inflammation was defined when Matts' histological grade was 2 or more. A cut-off value of the FI for active inflammation was determined using a receiver operating characteristic (ROC) analysis. The inter-observer consistency was calculated by unweighted kappa statistics.
resultsThe correlation coefficient for the FI was inversely related to the histological severity (r = -0.558, p < 0.0001). The ROC analysis showed that the optimal cut-off value for the FI for active inflammation was 0.906. The average diagnostic accuracy of the FI was significantly higher than those of the CE (84.7 vs 78.5 %, p < 0.01). The kappa values for the inter-observer consistency of CE and the FI were 0.60 and 0.95 in all participants, 0.53 and 0.97 in the less-experienced endoscopists group and 0.67 and 0.93 in the expert group, respectively.
conclusionsThe quantified AFI is considered to be an accurate and objective indicator that can be used to assess the activity of ulcerative colitis, particularly for less-experienced endoscopists.
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