ArticleInternational journal of molecular sciences2015
Interleukin-17A Gene Expression in Morbidly Obese Women.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of acupuncture on asthma control and body weight changes in obese patients with asthma.Frontiers in medicine · 2026Article
- The role of adipogenic niche resident cells in colorectal cancer progression in relation to obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- High-fat diet-induced adipose tissue-resident macrophages, T cells, and dendritic cells modulate chronic inflammation and adipogenesis during obesity.Frontiers in immunology · 2025Article
- Review
- Bacteroides ovatus-mediated CD27Cellular & molecular immunology · 2022Article
- Body mass index and adipokines/cytokines dysregulation in systemic sclerosis.Clinical and experimental immunology · 2021Article
- Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice.Nature metabolism · 2021Article
- Setting the Stage for Islet Autoimmunity in Type 2 Diabetes: Obesity-Associated Chronic Systemic Inflammation and Endoplasmic Reticulum (ER) Stress.Diabetes care · 2019Review
- Cellular mechanisms underlying obesity-induced arterial stiffness.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes.Molecular metabolism · 2017Article
- Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity.World journal of biological chemistry · 2017Review
- The obesity-related pathology and Th17 cells.Cellular and molecular life sciences : CMLS · 2017Review
- Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis.World journal of gastroenterology · 2016Review
- Interleukins 6 and 15 Levels Are Higher in Subcutaneous Adipose Tissue, but Obesity Is Associated with Their Increased Content in Visceral Fat Depots.International journal of molecular sciences · 2015Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data from recent studies conducted in rodent models and humans suggest that interleukin-17A (IL-17A) plays a role in the induction of inflammation in adipose tissue during obesity. The aim of this study was to assess the gene expression of IL-17A in adipose tissue of morbidly obese patients. We used RT-PCR to evaluate the expression of IL-17A and several adipo/cytokines in the visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) of 10 normal-weight control women (BMI < 25 kg/m2) and 30 morbidly obese women (MO, BMI > 40 kg/m2). We measured serum levels of IL-17A and adipo/cytokines in MO and normal weight women. IL-17A expression was significantly higher in VAT than in SAT in MO patients (p = 0.0127). It was very low in normal-weight controls in both VAT and SAT tissues. We found positive correlations between IL-17A and IL-6, lipocalin-2 and resistin in VAT of MO patients. The circulating level of IL-17A was higher in the normal-weight group than the MO patients (p = 0.032), and it was significantly related to adiponectin and TNFRII levels. In conclusion, IL-17A expression in VAT is increased in morbidly obese women, which suggests a link between obesity and innate immunity in low-grade chronic inflammation in morbidly obese women.
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