ArticleMolecules (Basel, Switzerland)2015
Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Role of Sulphur and Heavier Chalcogens on the Antioxidant Power and Bioactivity of Natural Phenolic Compounds.Biomolecules · 2022Review
- Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Selenium Anticancer Properties and Impact on Cellular Redox Status.Antioxidants (Basel, Switzerland) · 2020Review
- Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides.Molecules (Basel, Switzerland) · 2019Article
- Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension.Nutrients · 2019Article
- Inhibition and Inactivation of UropathogenicInternational journal of molecular sciences · 2018Article
- Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms.Antioxidants (Basel, Switzerland) · 2018Article
- Natural Nanoparticles: A Particular Matter Inspired by Nature.Antioxidants (Basel, Switzerland) · 2017Review
- Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens.Molecules (Basel, Switzerland) · 2017Article
- The Reactive Sulfur Species Concept: 15 Years On.Antioxidants (Basel, Switzerland) · 2017Review
- High throughput microencapsulation of Bacillus subtilis in semi-permeable biodegradable polymersomes for selenium remediation.Applied microbiology and biotechnology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium is traditionally considered as an antioxidant element and selenium compounds are often discussed in the context of chemoprevention and therapy. Recent studies, however, have revealed a rather more colorful and diverse biological action of selenium-based compounds, including the modulation of the intracellular redox homeostasis and an often selective interference with regulatory cellular pathways. Our basic activity and mode of action studies with simple selenium and tellurium salts in different strains of Staphylococcus aureus (MRSA) and Saccharomyces cerevisiae indicate that such compounds are sometimes not particularly toxic on their own, yet enhance the antibacterial potential of known antibiotics, possibly via the bioreductive formation of insoluble elemental deposits. Whilst the selenium and tellurium compounds tested do not necessarily act via the generation of Reactive Oxygen Species (ROS), they seem to interfere with various cellular pathways, including a possible inhibition of the proteasome and hindrance of DNA repair. Here, organic selenides are considerably more active compared to simple salts. The interference of selenium (and tellurium) compounds with multiple targets could provide new avenues for the development of effective antibiotic and anticancer agents which may go well beyond the traditional notion of selenium as a simple antioxidant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.