ArticlePloS one2015
Transcriptomic Analysis of Metabolic Pathways in Milkfish That Respond to Salinity and Temperature Changes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Dietary mannitol improves salinity adaptation in Nile tilapia (Oreochromis niloticus) by enhancing ion regulation, energy metabolism and antioxidant defense.Fish physiology and biochemistry · 2026Article
- Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub.Ecology and evolution · 2026Article
- Salinity-dependent responses differentiate branchial ion regulation during acute hypothermal stress in euryhaline Indian Medaka.Fish physiology and biochemistry · 2025Article
- Effects of Environmentally Friendly Aquaculture Chamber Coatings on Enzyme Activities, Histology, and Transcriptome in the Liver of Larimichthys crocea.Marine biotechnology (New York, N.Y.) · 2025Article
- Article
- Transcriptome Analysis Reveals Immune and Antioxidant Defense Mechanisms in theAnimals : an open access journal from MDPI · 2024Article
- Attenuative effects of collagen peptide from milkfish (Food science & nutrition · 2024Article
- Integrated Transcriptomic and Metabolomic Analyses Reveal Low-Temperature Tolerance Mechanism in Giant Freshwater PrawnAnimals : an open access journal from MDPI · 2023Article
- Freshwater transfer affected intestinal microbiota with correlation to cytokine gene expression in Asian sea bass.Frontiers in microbiology · 2023Article
- Genetic Mechanism of Tissue-Specific Expression ofInternational journal of molecular sciences · 2022Article
- Differentially Expressed miRNAs and mRNAs in Regenerated Scales of Rainbow Trout (Animals : an open access journal from MDPI · 2022Article
- Identification of Genes Related to Cold Tolerance and Novel Genetic Markers for Molecular Breeding in Taiwan Tilapia (Animals : an open access journal from MDPI · 2021Article
- RNA-seq analysis reveals divergent adaptive response to hyper- and hypo-salinity in cobia, Rachycentron canadum.Fish physiology and biochemistry · 2020Article
- Nevertheless, She Resisted - Role of the Environment onFrontiers in microbiology · 2020Article
- Changes in hypothermal stress-induced hepatic mitochondrial metabolic patterns between fresh water- and seawater-acclimated milkfish, Chanos chanos.Scientific reports · 2019Article
- The regulation of oxidative phosphorylation pathway on Vibrio alginolyticus adhesion under adversities.MicrobiologyOpen · 2019Article
- Multiple model species selection for transcriptomics analysis of non-model organisms.BMC bioinformatics · 2018Article
- Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis.BMC genomics · 2018Article
- Salinity Effects on Strategies of Glycogen Utilization in Livers of Euryhaline Milkfish (Frontiers in physiology · 2018Article
- Transcriptomic response to thermal and salinity stress in introduced and native sympatric Palaemon caridean shrimps.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Milkfish (Chanos chanos), an important marine aquaculture species in southern Taiwan, show considerable euryhalinity but have low tolerance to sudden drops in water temperatures in winter. Here, we used high throughput next-generation sequencing (NGS) to identify molecular and biological processes involved in the responses to environmental changes. Preliminary tests revealed that seawater (SW)-acclimated milkfish tolerated lower temperatures than the fresh water (FW)-acclimated group. Although FW- and SW-acclimated milkfish have different levels of tolerance for hypothermal stress, to date, the molecular physiological basis of this difference has not been elucidated. Here, we performed a next-generation sequence analysis of mRNAs from four groups of milkfish. We obtained 29669 unigenes with an average length of approximately 1936 base pairs. Gene ontology (GO) analysis was performed after gene annotation. A large number of genes for molecular regulation were identified through a transcriptomic comparison in a KEGG analysis. Basal metabolic pathways involved in hypothermal tolerance, such as glycolysis, fatty acid metabolism, amino acid catabolism and oxidative phosphorylation, were analyzed using PathVisio and Cytoscape software. Our results indicate that in response to hypothermal stress, genes for oxidative phosphorylation, e.g., succinate dehydrogenase, were more highly up-regulated in SW than FW fish. Moreover, SW and FW milkfish used different strategies when exposed to hypothermal stress: SW milkfish up-regulated oxidative phosphorylation and catabolism genes to produce more energy budget, whereas FW milkfish down-regulated genes related to basal metabolism to reduce energy loss.
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