ArticlePloS one2015
New Delhi Metallo-β-Lactamase 1(NDM-1), the Dominant Carbapenemase Detected in Carbapenem-Resistant Enterobacter cloacae from Henan Province, China.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Genomic Epidemiology of NDM-1 Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- Characterization of non-O157 enterohemorrhagic Escherichia coli isolated from different sources in Egypt.BMC microbiology · 2024Article
- Tn3-like structures co-harboring of blaBMC veterinary research · 2023Article
- Multidrug-ResistantMicroorganisms · 2023Article
- Molecular eidemiology of carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital in Shandong, China.BMC microbiology · 2023Article
- Genomic and clinical characteristics of carbapenem-resistantFrontiers in microbiology · 2023Article
- Emergence of Neonatal Sepsis Caused by MCR-9- and NDM-1-Co-ProducingFrontiers in cellular and infection microbiology · 2022Article
- Molecular characterization of NDM-1-producing carbapenem-resistantFrontiers in cellular and infection microbiology · 2022Article
- Co-Production of NDM-1 and OXA-10 β-Lactamase inInfection and drug resistance · 2022Article
- Nosocomial cluster of carbapenemase-producing Enterobacter cloacae in an intensive care unit dedicated COVID-19.Antimicrobial resistance and infection control · 2021Article
- Genetic basis of molecular mechanisms in β-lactam resistant gram-negative bacteria.Microbial pathogenesis · 2021Review
- Molecular characterization of carbapenem-resistantJournal of medical microbiology · 2021Article
- Emergence ofInfection and drug resistance · 2021Article
- Molecular Characterization ofFrontiers in microbiology · 2021Article
- Molecular Characteristics of Carbapenem-ResistantInfection and drug resistance · 2020Article
- High Prevalence of Metallo-β-Lactamase-ProducingFrontiers in microbiology · 2019Article
- Molecular characterization and epidemiology of carbapenem non-susceptible Enterobacteriaceae isolated from the Eastern region of Heilongjiang Province, China.BMC infectious diseases · 2018Article
- Spread of Plasmid-Encoded NDM-1 and GES-5 Carbapenemases among Extensively Drug-Resistant and Pandrug-Resistant Clinical Enterobacteriaceae in Durban, South Africa.Antimicrobial agents and chemotherapy · 2018Article
- Molecular Characterization of Carbapenem-ResistantFrontiers in microbiology · 2018Article
- Carbapenem-ResistantFrontiers in microbiology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of New Delhi metallo-β-lactamase 1 (NDM-1) has become established as a major public health threat and represents a new challenge in the treatment of infectious diseases. In this study, we report a high incidence and endemic spread of NDM-1-producing carbapenem-resistant Enterobacter cloacae isolates in Henan province, China. Eight (72.7%) out of eleven non-duplicated carbapenem-resistant E. cloacae isolates collected between June 2011 and May 2013 were identified as NDM-1 positive. The blaNDM-1 gene surrounded by an entire ISAba125 element and a bleomycin resistance gene bleMBL in these isolates were carried by diverse conjugatable plasmids (IncA/C, IncN, IncHI2 and untypeable) ranging from ~55 to ~360 kb. Molecular epidemiology analysis revealed that three NDM-1-producing E. cloacae belonged to the same multilocus sequence type (ST), ST120, two of which were classified as extensively drug-resistant (XDR) isolates susceptible only to tigecycline and colistin. The two XDR ST120 E. cloacae isolates co-harbored blaNDM-1, armA and fosA3 genes and could transfer resistance to carbapenems, fosfomycin and aminoglycosides simultaneously via a conjugation experiment. Our study demonstrated NDM-1 was the most prevalent metallo-β-lactamase (MBL) among carbapenem-resistant E.cloacae isolates and identified a potential endemic clone of ST120 in Henan province. These findings highlight the need for enhanced efforts to monitor the further spread of NDM-1 and XDR ST120 E. cloacae in this region.
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