ArticleBritish journal of cancer2015
The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer.
Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tumor Budding as a Marker for Poor Prognosis and Epithelial-Mesenchymal Transition in Lung Cancer: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Tumour budding in oral squamous cell carcinoma: a meta-analysis.British journal of cancer · 2018Pooled it
- Tumor Budding Unveiled: Clinicopathological Correlations and Survival Insights From a Tertiary Care Cancer Center of India.International journal of breast cancer · 2026Article
- Tumor budding in preoperative breast biopsies predicts sentinel lymph node metastasis.Biomolecules & biomedicine · 2025Article
- Tumor-Infiltrating Lymphocytes and Tumor Budding: Emerging Prognostic Markers in Breast Cancer.Cureus · 2025Article
- Tumor budding in invasive breast carcinoma and its association with clinicopathological parameters: an experience from a tertiary care center in India.Korean journal of clinical oncology · 2025Article
- Tumor Budding: A Novel Prognostic Marker in Breast Carcinoma with Correlation of Histopathological and Immunohistochemical Parameters.South Asian journal of cancer · 2025Article
- Tumour budding in invasive ductal breast carcinomas: correlation with clinicopathological prognostic parameters and hormone receptor status.Pathology oncology research : POR · 2025Article
- Expression of Ki-67 in Invasive Breast Carcinoma and Its Correlation With Different Clinicopathological Features.Cureus · 2024Article
- Analyzing Tumor Budding Scores in Invasive Breast Carcinoma: A Tertiary Care Center Study in South India.Journal of pharmacy & bioallied sciences · 2024Article
- Study of tumor budding and its association with clinicopathological parameters in breast carcinoma.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Investigation of the Relationship Between Tumor Microenvironment and Prognostic Parameters in Invasive Breast Carcinomas of No Special Type: A Retrospective Analysis.Turk patoloji dergisi · 2024Article
- Tumor stromal topography promotes chemoresistance in migrating breast cancer cell clusters.Biomaterials · 2023Article
- Tumor budding in invasive breast carcinoma: correlation with clinicopathological parameters, hormone receptor status, and survival: an observational study.Revista da Associacao Medica Brasileira (1992) · 2023Observational
- Expression of cytotoxic T lymphocyte-associated antigen 4, CD44, and E-cadherin in the microenvironment of breast carcinomas.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Tumour budding is a novel marker in breast cancer: the clinical application and future prospects.Annals of medicine · 2022Review
- A Retrospective Study of Association of Tumor Budding, Tumor Microenvironment, and Clinicopathological Characteristics of Invasive Breast Carcinoma.Journal of laboratory physicians · 2022Article
- Article
- Review
- Engineering a 3D collective cancer invasion model with control over collagen fiber alignment.Biomaterials · 2021Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTumour budding has previously been reported to predict survival in several solid organ tumours, including breast; however, whether this is independent of other aspects of the tumour microenvironment is unknown. In the present study, the relationship between tumour budding, the tumour microenvironment and survival was examined in patients with invasive ductal breast cancer.
methodsPatients presenting between 1995 and 1998 were studied (n=474). Using routine pathological sections, tumour budding was measured at the invasive margin and its association with clinicopathological characteristics and cancer-specific survival (CSS) was examined.
resultsTumour budding was associated with several adverse pathological characteristics, including lymph node involvement, lymph vessel invasion (LVI), increased tumour stroma percentage (TSP) and weaker local inflammatory infiltrative. Tumour budding was associated with reduced CSS (hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.14-3.09, P=0.004), independent of nodal status, molecular subtypes, tumour necrosis, CD8+, CD138+, LVI, blood vessel invasion and TSP. Further, tumour budding was independently associated with reduced CSS in node-negative patients (HR 2.63, 95% CI 1.16-5.92, P=0.020) and those who have low TSP (HR 1.98, 95% CI 1.09-3.57, P=0.024) and high-grade local inflammatory infiltrative (HR 2.27, 95% CI 1.35-5.36, P=0.014).
conclusionsTumour budding was a significant predictor of survival in patients with invasive ductal breast cancer, independent of adverse pathological characteristics and components of tumour microenvironment. The present study further confirms the clinical utility of both tumour and host-based factors of tumour microenvironment.
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