Evidence map›Paper›PMID 26263241›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2016

Chronotropic Incompetence and Dynamic Postexercise Autonomic Dysfunction Are Associated with the Presence and Severity of Erectile Dysfunction.

Nikolaos Ioakeimidis, Alexios Samentzas, Charalambos Vlachopoulos, Athanassios Aggelis, Christodoulos Stefanadis, Dimitrios Tousoulis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nikolaos IoakeimidisPeripheral Vessels and Hypertension Units, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece.
Alexios SamentzasPeripheral Vessels and Hypertension Units, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece.
Charalambos VlachopoulosPeripheral Vessels and Hypertension Units, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece.
Athanassios AggelisPeripheral Vessels and Hypertension Units, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece.
Christodoulos StefanadisPeripheral Vessels and Hypertension Units, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece.
Dimitrios TousoulisPeripheral Vessels and Hypertension Units, 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece.
Hippocration General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise stress testing (EST) is crucial to determine cardiovascular (CV) risk in men with erectile dysfunction (ED). Low exercise workload, a slower rate of recovery following exercise, and an impaired capacity to increase heart rate (HR) during exercise testing (chronotropic incompetence) are independent predictors of adverse CV outcomes. Aim of this study was to investigate the association between ED and EST parameters.

methodsA total of 180 ED patients and 50 men without ED underwent maximal EST. Exercise parameters including exercise capacity (metabolic equivalents, METS), peak exercise time, HR at six METS, peak exercise, HR recovery (HRR) at 1 and 2 minutes and chronotropic index (CI) were evaluated in all individuals. Endothelial function was evaluated with flow-mediated dilatation (FMD) of the brachial artery.

resultsED patients had lower peak exercise time and thus lower calculated exercise capacity (P < 0.001) and reduced CI (P < 0.01) compared to men without ED. There was a significant association of ED severity with duration of exercise, peak workload, HRR 2 minutes after exercise, and CI (all P < 0.05). There also was a positive relation of HRR and CI with FMD (all P < 0.05).

conclusionsThis study shows interrelationships between exercise capacity, HRR, CI, and ED. Abnormal HRR and CI are associated with systemic endothelial dysfunction. These findings imply pathophysiological links and may have important implications for the estimation of cardiovascular risk in ED patients.

Indexed as

Exercise TestAutonomic Nervous SystemBrachial ArteryEchocardiography, Doppler, ColorElectrocardiographyErectile DysfunctionHeart Rate DeterminationHumansMaleMiddle AgedRisk FactorsSeverity of Illness Indexchronotropic indexerectile dysfunctionexercise capacityexercise stress testheart rate recovery

Identifiers

PMID26263241
PMCPMC6931718
OpenAlexW1890140702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.