ArticleEpilepsy & behavior : E&B2015
Cognition and behavior in a prevalent cohort of children with epilepsy in rural northern Tanzania: A three-year follow-up study.
Article in Epilepsy & behavior : E&B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Comorbidities of epilepsy in low and middle-income countries: systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Prevalence and factors associated with intellectual impairment in children with epilepsy in two national referral hospitals in Uganda.Acta epileptologica · 2026Article
- The role of social context in cognitive and neurobehavioural outcomes in epilepsy.Nature reviews. Neurology · 2026Review
- Long-term characterization of behavior phenotypes in children with seizures: Analytic approach matters.Epilepsia · 2025Article
- Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelialMedComm · 2022Article
- Cognition, Behavior, and Psychosocial Effects of Seizures in the Developing Brain.Current topics in behavioral neurosciences · 2022Article
- Cognitive and physical development in HIV-positive children in South Africa and Malawi: A community-based follow-up comparison study.Child: care, health and development · 2018Article
- Could cash and good parenting affect child cognitive development? A cross-sectional study in South Africa and Malawi.BMC pediatrics · 2017Article
- Magnitude of Cognitive Impairment Among Patients With Epilepsy at Health Institutions in Gurage Zone, Ethiopia.SAGE open nursingArticle
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesEighty-five percent of the 33 million children with epilepsy (CWE) worldwide live in low- and middle-income countries (LMICs). There is limited research into epilepsy-related comorbidities in LMICs, and there are no studies of the long-term progression of behavioral and intellectual difficulties in childhood epilepsy in sub-Saharan Africa. We aimed to assess behavior and cognition at three-year follow-up in CWE in rural Tanzania.
methodsIn 2010, a cross-sectional study identified 112 CWE 6 to 14years of age and 113 age- and sex-matched controls in the Hai district of northern Tanzania. From March to June 2013, cases and controls (now 10 to 18years of age) were followed up. At baseline, behavior was assessed using the Rutter A Questionnaire and cognition using the Goodenough-Harris Drawing Test. Details of current seizure frequency and antiepileptic drug (AED) use among CWE were collected.
resultsAt follow-up, cases had significantly more behavioral difficulties compared with controls (48% of 108 cases versus 14% of 103 controls (p<0.001)). Additionally, 69% of the cases and 16% of the controls had cognitive impairment (p<0.001). In CWE with decreased seizure frequency from baseline to follow-up, behavior had improved significantly. At follow-up, there was no significant difference in behavior between CWE with decreased seizure frequency and those with good seizure control throughout. SIGNIFICANCE: Behavioral difficulties and cognitive impairment are common among CWE in this population. Improved access to AED treatment and subsequent improved seizure control may reduce the frequency of behavioral difficulties seen in this population.
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